Seladoeneolignan A, a new neolignan from Selaginella doederleinii Hieron.
Objective: To study the chemical compositions from Selaginella doederleinii Hieron. Methods: The petroleum ether and ethyl acetate fractions of 80% ethanol extract of S. doederleinii were separated and purified by macroporous resin, silica gel, Sephadex LH-20 and semi-preparative HPLC, and then the...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-09-01
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| Series: | Journal of Holistic Integrative Pharmacy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2707368823000420 |
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| author | Minyu CHEN Ni ZHENG Wenqi LIU Dingrong WAN Rumei LU Xinzhou YANG |
| author_facet | Minyu CHEN Ni ZHENG Wenqi LIU Dingrong WAN Rumei LU Xinzhou YANG |
| author_sort | Minyu CHEN |
| collection | DOAJ |
| description | Objective: To study the chemical compositions from Selaginella doederleinii Hieron. Methods: The petroleum ether and ethyl acetate fractions of 80% ethanol extract of S. doederleinii were separated and purified by macroporous resin, silica gel, Sephadex LH-20 and semi-preparative HPLC, and then the structures of obtained compounds were identified by physicochemical properties and spectroscopical data. Results: A total of 7 compounds were isolated and identified as seladoeneolignan A (1), ethoxy-ferulate (2), 11-dien-19-oic acid (3), aurantiamide (4), 9,16-dioxo-10,12,14-octadeca-trienoic acid (5), amentoflavone (6), and 7,4’-di-0-methylrobustaflavone (7). Conclusion: Compound 1 was a new neolignan obtaind from S. doederleinii for the first time. Compounds 1, 6 and 7 were screened for antitumor activity in vitro, and the testing results showed that 3 compounds had low inhibitory activity on Hep-2 and Eca-109 tumor cells. |
| format | Article |
| id | doaj-art-2b9744c32fc04c43a92b77b6c8b9aa61 |
| institution | Kabale University |
| issn | 2707-3688 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Holistic Integrative Pharmacy |
| spelling | doaj-art-2b9744c32fc04c43a92b77b6c8b9aa612024-11-12T05:21:33ZengKeAi Communications Co., Ltd.Journal of Holistic Integrative Pharmacy2707-36882022-09-0133224229Seladoeneolignan A, a new neolignan from Selaginella doederleinii Hieron.Minyu CHEN0Ni ZHENG1Wenqi LIU2Dingrong WAN3Rumei LU4Xinzhou YANG5College of Pharmacy, Guangxi University of Chinese Medicine, Nanning Guangxi 530200, ChinaSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan Hubei 430074, ChinaSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan Hubei 430074, ChinaSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan Hubei 430074, ChinaCollege of Pharmacy, Guangxi University of Chinese Medicine, Nanning Guangxi 530200, ChinaCollege of Pharmacy, Guangxi University of Chinese Medicine, Nanning Guangxi 530200, China; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan Hubei 430074, China; Corresponding authorObjective: To study the chemical compositions from Selaginella doederleinii Hieron. Methods: The petroleum ether and ethyl acetate fractions of 80% ethanol extract of S. doederleinii were separated and purified by macroporous resin, silica gel, Sephadex LH-20 and semi-preparative HPLC, and then the structures of obtained compounds were identified by physicochemical properties and spectroscopical data. Results: A total of 7 compounds were isolated and identified as seladoeneolignan A (1), ethoxy-ferulate (2), 11-dien-19-oic acid (3), aurantiamide (4), 9,16-dioxo-10,12,14-octadeca-trienoic acid (5), amentoflavone (6), and 7,4’-di-0-methylrobustaflavone (7). Conclusion: Compound 1 was a new neolignan obtaind from S. doederleinii for the first time. Compounds 1, 6 and 7 were screened for antitumor activity in vitro, and the testing results showed that 3 compounds had low inhibitory activity on Hep-2 and Eca-109 tumor cells.http://www.sciencedirect.com/science/article/pii/S2707368823000420Selaginella doederleiniiNeolignansChemical composition |
| spellingShingle | Minyu CHEN Ni ZHENG Wenqi LIU Dingrong WAN Rumei LU Xinzhou YANG Seladoeneolignan A, a new neolignan from Selaginella doederleinii Hieron. Journal of Holistic Integrative Pharmacy Selaginella doederleinii Neolignans Chemical composition |
| title | Seladoeneolignan A, a new neolignan from Selaginella doederleinii Hieron. |
| title_full | Seladoeneolignan A, a new neolignan from Selaginella doederleinii Hieron. |
| title_fullStr | Seladoeneolignan A, a new neolignan from Selaginella doederleinii Hieron. |
| title_full_unstemmed | Seladoeneolignan A, a new neolignan from Selaginella doederleinii Hieron. |
| title_short | Seladoeneolignan A, a new neolignan from Selaginella doederleinii Hieron. |
| title_sort | seladoeneolignan a a new neolignan from selaginella doederleinii hieron |
| topic | Selaginella doederleinii Neolignans Chemical composition |
| url | http://www.sciencedirect.com/science/article/pii/S2707368823000420 |
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