Development and characterization of patient-derived xenograft models of colorectal cancer for testing new pharmacological substances

Development and characterization of patient-derived xenograft models of colorectal cancer for testing new pharmacological substances

The aim of the study was to create a patient-derived xenograft (PDX) model of human colorectal cancer and to determine its histologic and molecular characteristics, such as the status of KRAS, NRAS, and BRAF genes and the presence of microsatellite instability.Materials and methods. First generation...

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Bibliographic Details
Main Authors: A. S. Goncharova, E. N. Kolesnikov, G. Yu. Egorov, A. Yu. Maksimov, A. N. Shevchenko, E. M. Nepomnyashchaya, D. Yu. Gvaldin, L. Z. Kurbanova, D. V. Khodakova, S. O. Kit, O. Yu. Kaymakchi, A. V. Snezhko
Format: Article
Language:English
Published: Siberian State Medical University (Tomsk) 2023-01-01
Series:Бюллетень сибирской медицины
Subjects:
xenograft
colorectal cancer
<i>in vivo</i> models
pdx model
balb/c nude
Online Access:https://bulletin.ssmu.ru/jour/article/view/5019
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