Trimester and severity of SARS-CoV-2 infection during pregnancy and risk of hypertensive disorders in pregnancy
Objective SARS-CoV-2 infection during pregnancy has been linked with an increased risk of hypertensive disorders of pregnancy (HDP). The aim of this study was to examine how both trimester and severity of SARS-CoV-2 infection impact HDP.Methods We conducted a cohort study of SARS-CoV-2-infected indi...
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Taylor & Francis Group
2024-12-01
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| Series: | Hypertension in Pregnancy |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10641955.2024.2308922 |
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| author | Samantha E. Parker Bhavana Annapragada Idalis A. Chestnut Jessica Fuchs Annette Lee Vishakha Sabharwal Elisha M. Wachman Christina D. Yarrington |
| author_facet | Samantha E. Parker Bhavana Annapragada Idalis A. Chestnut Jessica Fuchs Annette Lee Vishakha Sabharwal Elisha M. Wachman Christina D. Yarrington |
| author_sort | Samantha E. Parker |
| collection | DOAJ |
| description | Objective SARS-CoV-2 infection during pregnancy has been linked with an increased risk of hypertensive disorders of pregnancy (HDP). The aim of this study was to examine how both trimester and severity of SARS-CoV-2 infection impact HDP.Methods We conducted a cohort study of SARS-CoV-2-infected individuals during pregnancy (n = 205) and examined the association between trimester and severity of infection with incidence of HDP using modified Poisson regression models to calculate risk ratios (RR) and 95% confidence intervals (CI). We stratified the analysis of trimester by severity to understand the role of timing of infection among those with similar symptomatology and also examined timing of infection as a continuous variable.Results Compared to a reference cohort from 2018, SARS-CoV-2 infection did not largely increase the risk of HDP (RR: 1.17; CI:0.90, 1.51), but a non-statistically significant higher risk of preeclampsia was observed (RR: 1.33; CI:0.89, 1.98), in our small sample. Among the SARS-CoV-2 cohort, severity was linked with risk of HDP, with infections requiring hospitalization increasing the risk of HDP compared to asymptomatic/mild infections. Trimester of infection was not associated with risk of HDP, but a slight decline in the risk of HDP was observed with later gestational week of infection. Among patients with asymptomatic or mild symptoms, SARS-CoV-2 in the first trimester conferred a higher risk of HDP compared to the third trimester (RR: 1.70; CI:0.77, 3.77), although estimates were imprecise.Conclusion SARS-CoV-2 infection in early pregnancy may increase the risk of HDP compared to infection later in pregnancy. |
| format | Article |
| id | doaj-art-2b83b2b3e0224bc4a8a50caa4acf6bf4 |
| institution | Kabale University |
| issn | 1064-1955 1525-6065 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hypertension in Pregnancy |
| spelling | doaj-art-2b83b2b3e0224bc4a8a50caa4acf6bf42024-12-06T08:56:53ZengTaylor & Francis GroupHypertension in Pregnancy1064-19551525-60652024-12-0143110.1080/10641955.2024.2308922Trimester and severity of SARS-CoV-2 infection during pregnancy and risk of hypertensive disorders in pregnancySamantha E. Parker0Bhavana Annapragada1Idalis A. Chestnut2Jessica Fuchs3Annette Lee4Vishakha Sabharwal5Elisha M. Wachman6Christina D. Yarrington7Department of Epidemiology, School of Public Health, Boston University, Boston, MA, USADepartment of Epidemiology, School of Public Health, Boston University, Boston, MA, USADepartment of Epidemiology, School of Public Health, Boston University, Boston, MA, USADepartment of Epidemiology, School of Public Health, Boston University, Boston, MA, USADepartment of Epidemiology, School of Public Health, Boston University, Boston, MA, USADepartment of Pediatrics, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USADepartment of Pediatrics, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USADepartment of Obstetrics and Gynecology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USAObjective SARS-CoV-2 infection during pregnancy has been linked with an increased risk of hypertensive disorders of pregnancy (HDP). The aim of this study was to examine how both trimester and severity of SARS-CoV-2 infection impact HDP.Methods We conducted a cohort study of SARS-CoV-2-infected individuals during pregnancy (n = 205) and examined the association between trimester and severity of infection with incidence of HDP using modified Poisson regression models to calculate risk ratios (RR) and 95% confidence intervals (CI). We stratified the analysis of trimester by severity to understand the role of timing of infection among those with similar symptomatology and also examined timing of infection as a continuous variable.Results Compared to a reference cohort from 2018, SARS-CoV-2 infection did not largely increase the risk of HDP (RR: 1.17; CI:0.90, 1.51), but a non-statistically significant higher risk of preeclampsia was observed (RR: 1.33; CI:0.89, 1.98), in our small sample. Among the SARS-CoV-2 cohort, severity was linked with risk of HDP, with infections requiring hospitalization increasing the risk of HDP compared to asymptomatic/mild infections. Trimester of infection was not associated with risk of HDP, but a slight decline in the risk of HDP was observed with later gestational week of infection. Among patients with asymptomatic or mild symptoms, SARS-CoV-2 in the first trimester conferred a higher risk of HDP compared to the third trimester (RR: 1.70; CI:0.77, 3.77), although estimates were imprecise.Conclusion SARS-CoV-2 infection in early pregnancy may increase the risk of HDP compared to infection later in pregnancy.https://www.tandfonline.com/doi/10.1080/10641955.2024.2308922COVID-19gestational hypertensionpreeclampsiapregnancytrimester |
| spellingShingle | Samantha E. Parker Bhavana Annapragada Idalis A. Chestnut Jessica Fuchs Annette Lee Vishakha Sabharwal Elisha M. Wachman Christina D. Yarrington Trimester and severity of SARS-CoV-2 infection during pregnancy and risk of hypertensive disorders in pregnancy Hypertension in Pregnancy COVID-19 gestational hypertension preeclampsia pregnancy trimester |
| title | Trimester and severity of SARS-CoV-2 infection during pregnancy and risk of hypertensive disorders in pregnancy |
| title_full | Trimester and severity of SARS-CoV-2 infection during pregnancy and risk of hypertensive disorders in pregnancy |
| title_fullStr | Trimester and severity of SARS-CoV-2 infection during pregnancy and risk of hypertensive disorders in pregnancy |
| title_full_unstemmed | Trimester and severity of SARS-CoV-2 infection during pregnancy and risk of hypertensive disorders in pregnancy |
| title_short | Trimester and severity of SARS-CoV-2 infection during pregnancy and risk of hypertensive disorders in pregnancy |
| title_sort | trimester and severity of sars cov 2 infection during pregnancy and risk of hypertensive disorders in pregnancy |
| topic | COVID-19 gestational hypertension preeclampsia pregnancy trimester |
| url | https://www.tandfonline.com/doi/10.1080/10641955.2024.2308922 |
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