Advanced Computational Pipeline for FAK Inhibitor Discovery: Combining Multiple Docking Methods with MD and QSAR for Cancer Therapy

Advanced Computational Pipeline for FAK Inhibitor Discovery: Combining Multiple Docking Methods with MD and QSAR for Cancer Therapy

Synthetic lethality, involving the simultaneous deactivation of two genes, disrupts cellular functions or induces cell death. This study examines its role in cancer, focusing on focal adhesion kinase and Neurofibromin 2. Inhibiting FAK, crucial for synthetic lethality with NF2/Merlin, offers signifi...

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Bibliographic Details
Main Author:	Pinar Siyah
Format:	Article
Language:	English
Published:	MDPI AG 2024-11-01
Series:	Computation
Subjects:	focal adhesion kinase small molecules inhibitors docking IFD QPLD
Online Access:	https://www.mdpi.com/2079-3197/12/11/222
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