Cytokines and HIV associated neurological manifestations: a systematic review
Background. Cytokines are key players in the immune system’s reaction to HIV and play a crucial role in HIV pathogenesis. Dysregulation of cytokines can contribute to the disease’s pathogenesis and associated complications, making a comprehensive understanding of their roles crucial for developing e...
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| Format: | Article |
| Language: | Russian |
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Sankt-Peterburg : NIIÈM imeni Pastera
2025-04-01
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| Series: | Инфекция и иммунитет |
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| Online Access: | https://iimmun.ru/iimm/article/viewFile/17533/2158 |
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| author | S. SeyedAlinaghi A.M. Afsahi P. Mirzapour S. Alikarami A. Afzalian P. Matini S. Mahrokhi Z. Ali A. Pashaei S. Eslami F. Vahedi P. Paranjkhoo M.A. Habibi A. Molla A. Dadjou S.N. Parikhani Esmaeil Mehraeen D. Hackett |
| author_facet | S. SeyedAlinaghi A.M. Afsahi P. Mirzapour S. Alikarami A. Afzalian P. Matini S. Mahrokhi Z. Ali A. Pashaei S. Eslami F. Vahedi P. Paranjkhoo M.A. Habibi A. Molla A. Dadjou S.N. Parikhani Esmaeil Mehraeen D. Hackett |
| author_sort | S. SeyedAlinaghi |
| collection | DOAJ |
| description | Background. Cytokines are key players in the immune system’s reaction to HIV and play a crucial role in HIV pathogenesis. Dysregulation of cytokines can contribute to the disease’s pathogenesis and associated complications, making a comprehensive understanding of their roles crucial for developing efficacious therapeutic interventions against HIV/AIDS. Therefore, the aim of this systematic review is to examine the role of cytokines in HIV associated neurological manifestations and related complications. Materials and methods. Databases such as PubMed, Scopus, Web of Science, and Embase were explored for original English literature until September 10, 2022. Eligible articles for data extraction were screened and selected in two steps using some inclusion/ exclusion criteria. This study conforms to the PRISMA checklist and Newcastle-Ottawa Scale (NOS). Results. This review included a total of 15 studies. It was identified that cytokines were associated with sleep problems and numerous neurological manifestations. The most common neurological conditions include dementia, seizure, meningitis, cerebral toxoplasmosis, microcephalus, encephalitis, and gliosis. Commonly used cytokines detection methods included PCR, ELISA, Luminex xMAP multiplex platform, and PUREGene DNA Isolation System. Cytokine samples were mostly taken from blood and tissue. Conclusion. There is an interconnecting pathway of cytokines, neurological function (mainly dementia), and sleep habits in people living with HIV. Despite this, the mechanism of cytokines influencing sleep problems and neuropathological disorders remains unclear. Further research is warranted to determine the potential mechanisms and impact of cytokines associations in HIV progression. |
| format | Article |
| id | doaj-art-2b4d21361c3d414e9d26f554f99c8730 |
| institution | Kabale University |
| issn | 2220-7619 2313-7398 |
| language | Russian |
| publishDate | 2025-04-01 |
| publisher | Sankt-Peterburg : NIIÈM imeni Pastera |
| record_format | Article |
| series | Инфекция и иммунитет |
| spelling | doaj-art-2b4d21361c3d414e9d26f554f99c87302025-08-20T03:52:43ZrusSankt-Peterburg : NIIÈM imeni PasteraИнфекция и иммунитет2220-76192313-73982025-04-0115111212410.15789/2220-7619-CAH-175331502Cytokines and HIV associated neurological manifestations: a systematic reviewS. SeyedAlinaghi0A.M. Afsahi1P. Mirzapour2S. Alikarami3A. Afzalian4P. Matini5S. Mahrokhi6Z. Ali7A. Pashaei8S. Eslami9F. Vahedi10P. Paranjkhoo11M.A. Habibi12A. Molla13A. Dadjou14S.N. Parikhani15Esmaeil Mehraeen16D. Hackett17Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical SciencesUniversity of CaliforniaIranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical SciencesTehran University of Medical SciencesTehran University of Medical SciencesIran University of Medical SciencesIranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical SciencesUniversity of SaskatchewanIranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical SciencesTehran University of Medical SciencesTehran University of Medical SciencesAmerican University of ArmeniaQom University of Medical SciencesBushehr University of Medical SciencesBushehr University of Medical SciencesTehran University of Medical SciencesKhalkhal University of Medical SciencesThe University of SydneyBackground. Cytokines are key players in the immune system’s reaction to HIV and play a crucial role in HIV pathogenesis. Dysregulation of cytokines can contribute to the disease’s pathogenesis and associated complications, making a comprehensive understanding of their roles crucial for developing efficacious therapeutic interventions against HIV/AIDS. Therefore, the aim of this systematic review is to examine the role of cytokines in HIV associated neurological manifestations and related complications. Materials and methods. Databases such as PubMed, Scopus, Web of Science, and Embase were explored for original English literature until September 10, 2022. Eligible articles for data extraction were screened and selected in two steps using some inclusion/ exclusion criteria. This study conforms to the PRISMA checklist and Newcastle-Ottawa Scale (NOS). Results. This review included a total of 15 studies. It was identified that cytokines were associated with sleep problems and numerous neurological manifestations. The most common neurological conditions include dementia, seizure, meningitis, cerebral toxoplasmosis, microcephalus, encephalitis, and gliosis. Commonly used cytokines detection methods included PCR, ELISA, Luminex xMAP multiplex platform, and PUREGene DNA Isolation System. Cytokine samples were mostly taken from blood and tissue. Conclusion. There is an interconnecting pathway of cytokines, neurological function (mainly dementia), and sleep habits in people living with HIV. Despite this, the mechanism of cytokines influencing sleep problems and neuropathological disorders remains unclear. Further research is warranted to determine the potential mechanisms and impact of cytokines associations in HIV progression.https://iimmun.ru/iimm/article/viewFile/17533/2158hivaidscytokinesinfectionhiv infectionneuropathological disorder |
| spellingShingle | S. SeyedAlinaghi A.M. Afsahi P. Mirzapour S. Alikarami A. Afzalian P. Matini S. Mahrokhi Z. Ali A. Pashaei S. Eslami F. Vahedi P. Paranjkhoo M.A. Habibi A. Molla A. Dadjou S.N. Parikhani Esmaeil Mehraeen D. Hackett Cytokines and HIV associated neurological manifestations: a systematic review Инфекция и иммунитет hiv aids cytokines infection hiv infection neuropathological disorder |
| title | Cytokines and HIV associated neurological manifestations: a systematic review |
| title_full | Cytokines and HIV associated neurological manifestations: a systematic review |
| title_fullStr | Cytokines and HIV associated neurological manifestations: a systematic review |
| title_full_unstemmed | Cytokines and HIV associated neurological manifestations: a systematic review |
| title_short | Cytokines and HIV associated neurological manifestations: a systematic review |
| title_sort | cytokines and hiv associated neurological manifestations a systematic review |
| topic | hiv aids cytokines infection hiv infection neuropathological disorder |
| url | https://iimmun.ru/iimm/article/viewFile/17533/2158 |
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