Dual-functional biomimetic periosteum incorporating engineered small extracellular vesicles for treating critical bone defect with soft tissue fenestration via TGF-beta1/SMAD pathway

Dual-functional biomimetic periosteum incorporating engineered small extracellular vesicles for treating critical bone defect with soft tissue fenestration via TGF-beta1/SMAD pathway

Critical bone defect with soft tissue fenestration poses a significant therapeutic challenge without the premise of barrier periosteum in situ for the relatively independent repair spaces of soft tissue and bone. Inspired by the regenerative functions of mesenchymal stem cells (MSCs)-derived small e...

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Bibliographic Details
Main Authors: Zhengchuan Zhang, Jiaqi Shen, Ruogu Xu, Yang Yang, Xiaolin Yu, Dongsheng Yu, Feilong Deng
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Materials Today Bio
Subjects:
Critical bone defect
Biomimetic periosteum
Small extracellular vesicles
Soft tissue fenestration
Mesenchymal stem cells
Porous titanium
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425004521
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