Role of sgk1 in cancer: a bibliometric analysis from 2013 to 2023—review article
Abstract Serum and glucocorticoid-regulated kinase 1 (SGK1) plays a multifaceted role in cancer progression and treatment resistance. Its importance stems from its role in several cellular functions essential to cancer development, including metabolism, apoptosis, cell survival, and proliferation. I...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-11-01
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| Series: | Egyptian Journal of Medical Human Genetics |
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| Online Access: | https://doi.org/10.1186/s43042-024-00611-5 |
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| author | Wesam Ibrahim Abo- Elenien Samira G. Badawy Osama Abouelenin Farhan Khaleel Hussein Sakshi Kumari |
| author_facet | Wesam Ibrahim Abo- Elenien Samira G. Badawy Osama Abouelenin Farhan Khaleel Hussein Sakshi Kumari |
| author_sort | Wesam Ibrahim Abo- Elenien |
| collection | DOAJ |
| description | Abstract Serum and glucocorticoid-regulated kinase 1 (SGK1) plays a multifaceted role in cancer progression and treatment resistance. Its importance stems from its role in several cellular functions essential to cancer development, including metabolism, apoptosis, cell survival, and proliferation. In cancer, SGK1 expression is often dysregulated, leading to its overactivation or overexpression in many malignancies. This dysregulation can promote tumor growth, invasion, and metastasis through several mechanisms. We perform a bibliometric analysis to explore the role of SGK1 in cancer in the last ten years. All publications related to this topic were retrieved from the Scopus database. Microsoft Office Excel 2021 and VOSviewer (version 1.6.20) were used for the bibliometric analysis. The filtered search identified 5322 articles published between 2013 and 2023. Regarding research and scientific collaboration in this field, China is in the lead, followed by the USA, Germany, the UK, Japan, and Italy. In summary, SGK1 plays a critical role in cancer by regulating cell survival, proliferation, metabolism, and stemness. Its dysregulation promotes tumor growth, metastasis, and resistance to therapy. Targeting SGK1 is promising for enhancing cancer treatment efficacy, but further research is needed to fully understand its mechanisms and develop effective therapeutic strategies. Our study offers significant contributions to the field of cancer research by providing a comprehensive understanding of SGK1's role in cancer biology and highlighting its potential as a therapeutic target. These insights can inform future studies and guide the development of novel cancer prevention, diagnosis, and treatment approaches. |
| format | Article |
| id | doaj-art-2b32cf9b3bc14a0f9a43f0e9274d5a52 |
| institution | Kabale University |
| issn | 2090-2441 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Medical Human Genetics |
| spelling | doaj-art-2b32cf9b3bc14a0f9a43f0e9274d5a522024-12-01T12:29:06ZengSpringerOpenEgyptian Journal of Medical Human Genetics2090-24412024-11-0125111410.1186/s43042-024-00611-5Role of sgk1 in cancer: a bibliometric analysis from 2013 to 2023—review articleWesam Ibrahim Abo- Elenien0Samira G. Badawy1Osama Abouelenin2Farhan Khaleel Hussein3Sakshi Kumari4Faculty of Pharmacy, Alexandria UniversityFaculty of Physical Therapy, Misr University for Science and TechnologyFaculty of Medicine, Alexandria UniversityDepartment of Biology, College of Education for Pure Sciences, University of KirkukMbbs, Shimoga Institute of Medical SciencesAbstract Serum and glucocorticoid-regulated kinase 1 (SGK1) plays a multifaceted role in cancer progression and treatment resistance. Its importance stems from its role in several cellular functions essential to cancer development, including metabolism, apoptosis, cell survival, and proliferation. In cancer, SGK1 expression is often dysregulated, leading to its overactivation or overexpression in many malignancies. This dysregulation can promote tumor growth, invasion, and metastasis through several mechanisms. We perform a bibliometric analysis to explore the role of SGK1 in cancer in the last ten years. All publications related to this topic were retrieved from the Scopus database. Microsoft Office Excel 2021 and VOSviewer (version 1.6.20) were used for the bibliometric analysis. The filtered search identified 5322 articles published between 2013 and 2023. Regarding research and scientific collaboration in this field, China is in the lead, followed by the USA, Germany, the UK, Japan, and Italy. In summary, SGK1 plays a critical role in cancer by regulating cell survival, proliferation, metabolism, and stemness. Its dysregulation promotes tumor growth, metastasis, and resistance to therapy. Targeting SGK1 is promising for enhancing cancer treatment efficacy, but further research is needed to fully understand its mechanisms and develop effective therapeutic strategies. Our study offers significant contributions to the field of cancer research by providing a comprehensive understanding of SGK1's role in cancer biology and highlighting its potential as a therapeutic target. These insights can inform future studies and guide the development of novel cancer prevention, diagnosis, and treatment approaches.https://doi.org/10.1186/s43042-024-00611-5Bibliometric analysisBiomarkersCancer cell prefoliationMolecular mechanismSgk1 |
| spellingShingle | Wesam Ibrahim Abo- Elenien Samira G. Badawy Osama Abouelenin Farhan Khaleel Hussein Sakshi Kumari Role of sgk1 in cancer: a bibliometric analysis from 2013 to 2023—review article Egyptian Journal of Medical Human Genetics Bibliometric analysis Biomarkers Cancer cell prefoliation Molecular mechanism Sgk1 |
| title | Role of sgk1 in cancer: a bibliometric analysis from 2013 to 2023—review article |
| title_full | Role of sgk1 in cancer: a bibliometric analysis from 2013 to 2023—review article |
| title_fullStr | Role of sgk1 in cancer: a bibliometric analysis from 2013 to 2023—review article |
| title_full_unstemmed | Role of sgk1 in cancer: a bibliometric analysis from 2013 to 2023—review article |
| title_short | Role of sgk1 in cancer: a bibliometric analysis from 2013 to 2023—review article |
| title_sort | role of sgk1 in cancer a bibliometric analysis from 2013 to 2023 review article |
| topic | Bibliometric analysis Biomarkers Cancer cell prefoliation Molecular mechanism Sgk1 |
| url | https://doi.org/10.1186/s43042-024-00611-5 |
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