The role of gut microbiota in different murine models of systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by immune system dysfunction that can lead to serious health issues and mortality. Recent investigations highlight the role of gut microbiota alterations in modulating inflammation and disease severity in SLE. This review spe...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Autoimmunity |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/08916934.2024.2378876 |
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| _version_ | 1846141574890651648 |
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| author | Ran Lu Xin M. Luo |
| author_facet | Ran Lu Xin M. Luo |
| author_sort | Ran Lu |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by immune system dysfunction that can lead to serious health issues and mortality. Recent investigations highlight the role of gut microbiota alterations in modulating inflammation and disease severity in SLE. This review specifically summaries the variations in gut microbiota composition across various murine models of lupus. By focusing on these differences, we aim to elucidate the intricate relationship between gut microbiota dysbiosis and the development and progression of SLE in preclinical settings. |
| format | Article |
| id | doaj-art-2b2e3ffe33ba49ae9e273d267f1211a5 |
| institution | Kabale University |
| issn | 0891-6934 1607-842X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Autoimmunity |
| spelling | doaj-art-2b2e3ffe33ba49ae9e273d267f1211a52024-12-04T06:11:52ZengTaylor & Francis GroupAutoimmunity0891-69341607-842X2024-12-0157110.1080/08916934.2024.2378876The role of gut microbiota in different murine models of systemic lupus erythematosusRan Lu0Xin M. Luo1Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USADepartment of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USASystemic lupus erythematosus (SLE) is an autoimmune disorder characterized by immune system dysfunction that can lead to serious health issues and mortality. Recent investigations highlight the role of gut microbiota alterations in modulating inflammation and disease severity in SLE. This review specifically summaries the variations in gut microbiota composition across various murine models of lupus. By focusing on these differences, we aim to elucidate the intricate relationship between gut microbiota dysbiosis and the development and progression of SLE in preclinical settings.https://www.tandfonline.com/doi/10.1080/08916934.2024.2378876LupusSLEgut microbiotamouse modelsleaky gutmolecular mimicry |
| spellingShingle | Ran Lu Xin M. Luo The role of gut microbiota in different murine models of systemic lupus erythematosus Autoimmunity Lupus SLE gut microbiota mouse models leaky gut molecular mimicry |
| title | The role of gut microbiota in different murine models of systemic lupus erythematosus |
| title_full | The role of gut microbiota in different murine models of systemic lupus erythematosus |
| title_fullStr | The role of gut microbiota in different murine models of systemic lupus erythematosus |
| title_full_unstemmed | The role of gut microbiota in different murine models of systemic lupus erythematosus |
| title_short | The role of gut microbiota in different murine models of systemic lupus erythematosus |
| title_sort | role of gut microbiota in different murine models of systemic lupus erythematosus |
| topic | Lupus SLE gut microbiota mouse models leaky gut molecular mimicry |
| url | https://www.tandfonline.com/doi/10.1080/08916934.2024.2378876 |
| work_keys_str_mv | AT ranlu theroleofgutmicrobiotaindifferentmurinemodelsofsystemiclupuserythematosus AT xinmluo theroleofgutmicrobiotaindifferentmurinemodelsofsystemiclupuserythematosus AT ranlu roleofgutmicrobiotaindifferentmurinemodelsofsystemiclupuserythematosus AT xinmluo roleofgutmicrobiotaindifferentmurinemodelsofsystemiclupuserythematosus |