[18F]FDG PET/CT versus [18F]FDG PET/MRI in staging of non-small cell lung cancer: a head-to-head comparative meta-analysis
PurposeThis meta-analysis aims to compare the diagnostic efficacy of [18F]FDG PET/CT and [18F]FDG PET/MRI in patients with non-small cell lung cancer (NSCLC).MethodsAn extensive literature search was conducted throughout the PubMed, Embase, and Web of Science databases for works accessible through S...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1517805/full |
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| author | Dandan Yu Chaolin Chen |
| author_facet | Dandan Yu Chaolin Chen |
| author_sort | Dandan Yu |
| collection | DOAJ |
| description | PurposeThis meta-analysis aims to compare the diagnostic efficacy of [18F]FDG PET/CT and [18F]FDG PET/MRI in patients with non-small cell lung cancer (NSCLC).MethodsAn extensive literature search was conducted throughout the PubMed, Embase, and Web of Science databases for works accessible through September 2024. We included studies assessed the diagnostic efficacy of [18F]FDG PET/CT and [18F]FDG PET/MRI in NSCLC.ResultsThe meta-analysis includes six studies with a total of 437 patients. The sensitivity and specificity of [18F]FDG PET/CT and [18F]FDG PET/MRI for detecting lymph node metastasis were similar, at 0.82 (0.68–0.94) vs. 0.86 (0.70–0.97) and 0.88 (0.76–0.96) vs. 0.90 (0.85–0.94), respectively, with no significant differences (p = 0.70 for sensitivity, p = 0.75 for specificity). For distant metastasis, the sensitivity of [18F]FDG PET/CT and [18F]FDG PET/MRI was 0.86 (0.60–1.00) and 0.93 (0.63–1.00), and specificity was 0.89 (0.65–1.00) vs. 0.90 (0.64–1.00), respectively, also showing no significant differences (p = 0.66 for sensitivity, p = 0.97 for specificity).ConclusionOur meta-analysis shows that [18F]FDG PET/MRI has similar sensitivity and specificity to [18F]FDG PET/CT in identifying lymph node and distant metastases in patients with NSCLC. Additional larger sample prospective studies are needed to confirm these findings.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023479817, CRD42023479817. |
| format | Article |
| id | doaj-art-2b29efcb59c741b88107d6cad3e7c154 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-2b29efcb59c741b88107d6cad3e7c1542025-01-13T06:10:18ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.15178051517805[18F]FDG PET/CT versus [18F]FDG PET/MRI in staging of non-small cell lung cancer: a head-to-head comparative meta-analysisDandan YuChaolin ChenPurposeThis meta-analysis aims to compare the diagnostic efficacy of [18F]FDG PET/CT and [18F]FDG PET/MRI in patients with non-small cell lung cancer (NSCLC).MethodsAn extensive literature search was conducted throughout the PubMed, Embase, and Web of Science databases for works accessible through September 2024. We included studies assessed the diagnostic efficacy of [18F]FDG PET/CT and [18F]FDG PET/MRI in NSCLC.ResultsThe meta-analysis includes six studies with a total of 437 patients. The sensitivity and specificity of [18F]FDG PET/CT and [18F]FDG PET/MRI for detecting lymph node metastasis were similar, at 0.82 (0.68–0.94) vs. 0.86 (0.70–0.97) and 0.88 (0.76–0.96) vs. 0.90 (0.85–0.94), respectively, with no significant differences (p = 0.70 for sensitivity, p = 0.75 for specificity). For distant metastasis, the sensitivity of [18F]FDG PET/CT and [18F]FDG PET/MRI was 0.86 (0.60–1.00) and 0.93 (0.63–1.00), and specificity was 0.89 (0.65–1.00) vs. 0.90 (0.64–1.00), respectively, also showing no significant differences (p = 0.66 for sensitivity, p = 0.97 for specificity).ConclusionOur meta-analysis shows that [18F]FDG PET/MRI has similar sensitivity and specificity to [18F]FDG PET/CT in identifying lymph node and distant metastases in patients with NSCLC. Additional larger sample prospective studies are needed to confirm these findings.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023479817, CRD42023479817.https://www.frontiersin.org/articles/10.3389/fmed.2024.1517805/full[18F]FDG PET/CT[18F]FDG PET/MRInon-small cell lung cancermeta-analaysisstaging |
| spellingShingle | Dandan Yu Chaolin Chen [18F]FDG PET/CT versus [18F]FDG PET/MRI in staging of non-small cell lung cancer: a head-to-head comparative meta-analysis Frontiers in Medicine [18F]FDG PET/CT [18F]FDG PET/MRI non-small cell lung cancer meta-analaysis staging |
| title | [18F]FDG PET/CT versus [18F]FDG PET/MRI in staging of non-small cell lung cancer: a head-to-head comparative meta-analysis |
| title_full | [18F]FDG PET/CT versus [18F]FDG PET/MRI in staging of non-small cell lung cancer: a head-to-head comparative meta-analysis |
| title_fullStr | [18F]FDG PET/CT versus [18F]FDG PET/MRI in staging of non-small cell lung cancer: a head-to-head comparative meta-analysis |
| title_full_unstemmed | [18F]FDG PET/CT versus [18F]FDG PET/MRI in staging of non-small cell lung cancer: a head-to-head comparative meta-analysis |
| title_short | [18F]FDG PET/CT versus [18F]FDG PET/MRI in staging of non-small cell lung cancer: a head-to-head comparative meta-analysis |
| title_sort | 18f fdg pet ct versus 18f fdg pet mri in staging of non small cell lung cancer a head to head comparative meta analysis |
| topic | [18F]FDG PET/CT [18F]FDG PET/MRI non-small cell lung cancer meta-analaysis staging |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1517805/full |
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