FSTL1 aggravates high glucose-induced oxidative stress and transdifferentiation in HK-2 cells

FSTL1 aggravates high glucose-induced oxidative stress and transdifferentiation in HK-2 cells

Abstract Chronic hyperglycemia, a hallmark of diabetes, can trigger inflammatory responses in the kidney, leading to diabetic nephropathy (DN). Follistatin-like protein 1 (FSTL1) has emerged as a potential therapeutic target in various kidney diseases. This study investigated the effect of high gluc...

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Bibliographic Details
Main Authors: Baoyuan Zhang, Hang Geng, Kai Zhao, Moussa Omorou, Shuang Liu, Zhihui Ye, Fanting Zhang, Haiyan Luan, Xuesong Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Diabetic nephropathy
Follistatin-like protein 1
Oxidative stress
Transdifferentiation
Online Access:https://doi.org/10.1038/s41598-024-84462-5
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