Epidemiological profile trends and cost of pediatric sickle cell disease in Brazil from 2008 to 2022
Objective: This study aimed to investigate the epidemiological trends of Pediatric Sickle Cell Disease (SCD) in Brazil over the period 2008–2022, with a focus on understanding the incidence, mortality rates, and associated healthcare costs. The study explored potential associations between patient c...
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Elsevier
2025-01-01
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| Series: | Jornal de Pediatria |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0021755724001104 |
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| author | Luiza Telles Paulo Henrique Moreira Melo Luana Baptistele Dornelas Gabriele Eckerdt Lech Natália Zaneti Sampaio Ayla Gerk Madeleine Carroll Cristina Pires Camargo |
| author_facet | Luiza Telles Paulo Henrique Moreira Melo Luana Baptistele Dornelas Gabriele Eckerdt Lech Natália Zaneti Sampaio Ayla Gerk Madeleine Carroll Cristina Pires Camargo |
| author_sort | Luiza Telles |
| collection | DOAJ |
| description | Objective: This study aimed to investigate the epidemiological trends of Pediatric Sickle Cell Disease (SCD) in Brazil over the period 2008–2022, with a focus on understanding the incidence, mortality rates, and associated healthcare costs. The study explored potential associations between patient characteristics and the occurrence of crises in pediatric SCD cases. Methods: A cross-sectional study was conducted, analyzing national annual rates of pediatric SCD hospitalizations using data from the FioCruz platform. Descriptive and inferential analyses, including time series and ARIMA regression, were employed. Economic dimensions were assessed using cost categorization. The study followed STROBE reporting guidelines. Results: Data on 81,942 pediatric SCD hospitalizations were collected, with a predominance of crisis-related cases (74.08 %). Males and children under five years old were most affected. Regional disparities were observed, with the Southwest region recording the highest hospitalization rates. ICU costs were higher for crisis-related hospitalizations. Mortality rates were significantly higher for crisis-related cases (p < 0.001), with ARIMA regression indicating a significant association between hospitalizations for crisis-related cases and mortality. Conclusion: This study highlights the significant burden of pediatric SCD in Brazil, particularly crisis-related cases, suggesting a need for focused interventions. By prioritizing early detection, equitable access to healthcare, and evidence-based interventions, Brazil can mitigate the burden of SCD and improve patient outcomes. These findings contribute to informing public health policies and interventions aimed at addressing the challenges of pediatric SCD management in Brazil. |
| format | Article |
| id | doaj-art-2b0b2d57b3c5426cae5c460e933d4e29 |
| institution | Kabale University |
| issn | 0021-7557 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Jornal de Pediatria |
| spelling | doaj-art-2b0b2d57b3c5426cae5c460e933d4e292025-01-04T04:55:49ZengElsevierJornal de Pediatria0021-75572025-01-011011110116Epidemiological profile trends and cost of pediatric sickle cell disease in Brazil from 2008 to 2022Luiza Telles0Paulo Henrique Moreira Melo1Luana Baptistele Dornelas2Gabriele Eckerdt Lech3Natália Zaneti Sampaio4Ayla Gerk5Madeleine Carroll6Cristina Pires Camargo7Instituto de Educação Médica (IDOMED/Estácio, Campus Vista Carioca), Rio de Janeiro, RJ, Brazil; Corresponding author.Universidade Federal de Minas Gerais, Faculdade de Medicina, Belo Horizonte, MG, BrazilFaculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, SP, BrazilPontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, BrazilUniversidade de Araraquara, Araraquara, SP, BrazilHarvard Medical School, Program in Global Surgery and Social Change, Boston, United States; McGill University, Department of Surgical and Interventional Sciences, Quebec, Canada; Montreal Children's Hospital, Harvey E. Beardmore Division of Pediatric Surgery, Quebec, CanadaHarvard Medical School, Program in Global Surgery and Social Change, Boston, United StatesFaculdade de Medicina, Universidade de São Paulo, Microcirurgia Laboratorial e Cirurgia Plástica, São Paulo, SP, BrazilObjective: This study aimed to investigate the epidemiological trends of Pediatric Sickle Cell Disease (SCD) in Brazil over the period 2008–2022, with a focus on understanding the incidence, mortality rates, and associated healthcare costs. The study explored potential associations between patient characteristics and the occurrence of crises in pediatric SCD cases. Methods: A cross-sectional study was conducted, analyzing national annual rates of pediatric SCD hospitalizations using data from the FioCruz platform. Descriptive and inferential analyses, including time series and ARIMA regression, were employed. Economic dimensions were assessed using cost categorization. The study followed STROBE reporting guidelines. Results: Data on 81,942 pediatric SCD hospitalizations were collected, with a predominance of crisis-related cases (74.08 %). Males and children under five years old were most affected. Regional disparities were observed, with the Southwest region recording the highest hospitalization rates. ICU costs were higher for crisis-related hospitalizations. Mortality rates were significantly higher for crisis-related cases (p < 0.001), with ARIMA regression indicating a significant association between hospitalizations for crisis-related cases and mortality. Conclusion: This study highlights the significant burden of pediatric SCD in Brazil, particularly crisis-related cases, suggesting a need for focused interventions. By prioritizing early detection, equitable access to healthcare, and evidence-based interventions, Brazil can mitigate the burden of SCD and improve patient outcomes. These findings contribute to informing public health policies and interventions aimed at addressing the challenges of pediatric SCD management in Brazil.http://www.sciencedirect.com/science/article/pii/S0021755724001104Public healthPediatricSickle cell anemiaGlobal healthCost of illness |
| spellingShingle | Luiza Telles Paulo Henrique Moreira Melo Luana Baptistele Dornelas Gabriele Eckerdt Lech Natália Zaneti Sampaio Ayla Gerk Madeleine Carroll Cristina Pires Camargo Epidemiological profile trends and cost of pediatric sickle cell disease in Brazil from 2008 to 2022 Jornal de Pediatria Public health Pediatric Sickle cell anemia Global health Cost of illness |
| title | Epidemiological profile trends and cost of pediatric sickle cell disease in Brazil from 2008 to 2022 |
| title_full | Epidemiological profile trends and cost of pediatric sickle cell disease in Brazil from 2008 to 2022 |
| title_fullStr | Epidemiological profile trends and cost of pediatric sickle cell disease in Brazil from 2008 to 2022 |
| title_full_unstemmed | Epidemiological profile trends and cost of pediatric sickle cell disease in Brazil from 2008 to 2022 |
| title_short | Epidemiological profile trends and cost of pediatric sickle cell disease in Brazil from 2008 to 2022 |
| title_sort | epidemiological profile trends and cost of pediatric sickle cell disease in brazil from 2008 to 2022 |
| topic | Public health Pediatric Sickle cell anemia Global health Cost of illness |
| url | http://www.sciencedirect.com/science/article/pii/S0021755724001104 |
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