Trehalose enhances macrophage autophagy to promote myelin debris clearance after spinal cord injury

Trehalose enhances macrophage autophagy to promote myelin debris clearance after spinal cord injury

Abstract Background Myelin-laden foamy macrophages accumulate extensively in the lesion epicenter, exhibiting characteristics of autophagolysosomal dysfunction, which leads to prolonged inflammatory responses after spinal cord injury (SCI). Trehalose, known for its neuroprotective properties as an a...

Full description

Saved in:

Bibliographic Details
Main Authors:	Zhida Ma, Congpeng Meng, Xiang Wang, Yuanzhe Zhao, Jingwen Wang, Yihao Chen, Yiteng Li, Yan Jiang, Fangru Ouyang, Jianjian Li, Meige Zheng, Li Cheng, Juehua Jing
Format:	Article
Language:	English
Published:	BMC 2025-01-01
Series:	Cell & Bioscience
Subjects:	Trehalose Spinal cord injury Foamy macrophages Autophagy Myelin debris
Online Access:	https://doi.org/10.1186/s13578-025-01357-2
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

A review focuses on a neglected and controversial component of SCI: myelin debris
by: Yuchen Zhou, et al.
Published: (2024-11-01)

Macropinocytosis enhances foamy macrophage formation and cholesterol crystallization to activate NLRP3 inflammasome after spinal cord injury
by: Chenxi Zhang, et al.
Published: (2025-02-01)

Trehalose: Neuroprotective Effects and Mechanisms—An Updated Review
by: Borislav Sevriev, et al.
Published: (2024-10-01)

Taste Preference and Metabolic Rate of Trehalose in Chickens
by: Fuminori Kawabata, et al.
Published: (2025-01-01)

A review on the functional roles of trehalose during cryopreservation of small ruminant semen
by: Baoyu Jia, et al.
Published: (2024-11-01)

Comparative Sensitivity of MRI Indices for Myelin Assessment in Spinal Cord Regions
by: Philip Kyeremeh Jnr Oppong, et al.
Published: (2025-01-01)

Synthesis of trehalose-based chemical tools for the study of the mycobacterial membrane
by: Lesur, Emilie, et al.
Published: (2023-10-01)

Trehalose polyphleates participate in Mycobacterium abscessus fitness and pathogenesis
by: Silke Malmsheimer, et al.
Published: (2024-12-01)

Comparative profiling of white matter development in the human and mouse brain reveals volumetric deficits and delayed myelination in Angelman syndrome
by: Siddhi S. Ozarkar, et al.
Published: (2024-12-01)

Evaluation of Drought Tolerance and Trehalose Response in <i>Auricularia heimuer</i>
by: Jian Sun, et al.
Published: (2024-12-01)

In Vitro and In Vivo Evaluation of the Fertilization Capacity of Frozen/Thawed Rooster Spermatozoa Supplemented with Different Concentrations of Trehalose
by: Kristýna Petričáková, et al.
Published: (2024-12-01)

Review of Space Debris Modeling Methods and Development Direction of the Korean Space Debris Models
by: Jinsung Lee, et al.
Published: (2024-12-01)

Trehalose Ameliorates Zebrafish Emotional and Social Deficits Caused by CLN8 Dysfunction
by: Rosario Licitra, et al.
Published: (2025-01-01)

Effects of trehalose on bone healing, physical function, and pain in patients with pertrochanteric fractures: a randomized controlled trial protocol
by: Reza Zandi, et al.
Published: (2024-12-01)

Structural interactions of complex proteins with trehalose: mechanisms for improving the multilevel structure and functional properties of lentil-quinoa protein complexes
by: Mohammad Alrosan, et al.
Published: (2024-12-01)

The Participation of Trehalose Metabolism in Response to High-Humidity Stress in <i>Megoura crassicauda</i> (Hemiptera: Aphididae)
by: Wu Ma, et al.
Published: (2024-12-01)

Unilateral 360° Peripapillary Myelinated Nerve Fibers with Axial Myopia and Amblyopia: Straatsma Syndrome
by: Rajwinder Kaur, et al.
Published: (2024-12-01)

Targeting S100A9 attenuates social dysfunction by modulating neuroinflammation and myelination in a mouse model of autism
by: Hong Gong, et al.
Published: (2025-01-01)

The Effect of Trehalose on Dispersion of Ice Crystals and Consistency of Low-Fat Ice Cream
by: Landikhovskaya Anna V., et al.
Published: (2020-10-01)

Exogenous Trehalose Assists <i>Zygosaccharomyces rouxii</i> in Resisting High-Temperature Stress Mainly by Activating Genes Rather than Entering Metabolism
by: Xiong Xiao, et al.
Published: (2024-12-01)

Xanthogranulomatous Inflammation of Colon: A Case Report
by: Ramya Lakshminarayanan, et al.
Published: (2024-12-01)

Automated quantification of axonal and myelin changes in contusion, dislocation, and distraction spinal cord injuries: Insights into targeted remyelination and axonal regeneration
by: Xuan Li, et al.
Published: (2025-02-01)

Improved viability of trehalose on Lactobacillus plantarum embedded with whey protein concentrate/pullulan in simulated gastrointestinal conditions and its application in acid juice
by: Xiujuan Wang, et al.
Published: (2024-11-01)

Effects of Arginine Vasopressin on Hippocampal Myelination in an Autism Rat Model: A RNA-seq and Mendelian Randomization Analysis
by: Xingxing Bao, et al.
Published: (2024-11-01)

Correlation between myelin basic protein levels in cerebrospinal fluid and motor speed in patients with schizophrenia
by: Takako Enokida, et al.
Published: (2024-09-01)

Schwann Cell‐Specific Ablation of Beclin 1 Impairs Myelination and Leads to Motor and Sensory Neuropathy in Mice
by: Lisa Gambarotto, et al.
Published: (2025-02-01)

Real-World Treatment Outcomes of an Artificial Tear Containing Arabinogalactan, Hyaluronic Acid and Trehalose Among Subjects with Dry Eye
by: Bedei A, et al.
Published: (2025-01-01)

Imaging of the Vega Debris System Using JWST/MIRI
by: Kate Y. L. Su, et al.
Published: (2024-01-01)

Genome-wide identification and characterization of circular RNAs for exogenous trehalose-mediated heat stress responses in tea plants (Camellia sinensis)
by: Shizhong Zheng, et al.
Published: (2024-12-01)

Key Amino Acid Residues of the Agt1 Transporter for Trehalose Transport by <i>Saccharomyces cerevisiae</i>
by: Anqi Chen, et al.
Published: (2024-11-01)

Empirical and thermal resistance approaches for debris thickness estimation on the Hoksar Glacier, Kashmir Himalaya
by: Iram Ali, et al.
Published: (2024-12-01)

Delay in the flow of plant debris on floodplains overgrown with shrub vegetation
by: Mateusz Hämmerling, et al.
Published: (2014-12-01)

Oligodendrocyte-specific expression of PSG8-AS1 suggests a role in myelination with prognostic value in oligodendroglioma
by: Maria de los Angeles Becerra Rodriguez, et al.
Published: (2024-12-01)

A Comparative Study of Methods for Estimating the Thickness of Glacial Debris: A Case Study of the Koxkar Glacier in the Tian Shan Mountains
by: Jun Liu, et al.
Published: (2024-11-01)

Oligodendroglial heterogeneity in health, disease, and recovery: deeper insights into myelin dynamics
by: Pieter-Jan Serneels, et al.
Published: (2025-11-01)

Stabilizing milk-derived extracellular vesicles (mEVs) through lyophilization: a novel trehalose and tryptophan formulation for maintaining structure and Bioactivity during long-term storage
by: Alan B. Dogan, et al.
Published: (2025-01-01)

Clusterin induced by OPC phagocytosis blocks IL-9 secretion to inhibit myelination in a model of Alzheimer's disease
by: Rebecca M. Beiter, et al.
Published: (2025-01-01)

In-situ and modelled debris thickness distribution on Panchi Nala Glacier (western Himalaya, India) and its impact on glacier state
by: Purushottam Kumar Garg, et al.
Published: (2024-12-01)

Combined Physiological and Transcriptomic Analyses of the Effects of Exogenous Trehalose on Salt Tolerance in Maize (<i>Zea mays</i> L.)
by: Jingyi He, et al.
Published: (2024-12-01)

On the impact of debris accumulation on power production of marine hydrokinetic turbines: Insights gained via LES
by: Mustafa Meriç Aksen, et al.
Published: (2024-11-01)