Dual burden of infectious and chronic disease in low-resource U.S. communities: examining relationships between infection, adiposity, and inflammation
Background Rising global obesity rates are linked with inflammation and associated morbidities. These negative outcomes are generally more common in low-resource communities within high-income countries; however, it is unclear how frequent infectious disease exposures in these settings may influence...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Annals of Human Biology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/03014460.2024.2368851 |
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| author | Theresa E. Gildner Samuel S. Urlacher Katherine L. Nemeth Jade A. Beauregard Marcela Pfaff Nash Angela Zhang Sophie Waimon Tara J. Cepon-Robins |
| author_facet | Theresa E. Gildner Samuel S. Urlacher Katherine L. Nemeth Jade A. Beauregard Marcela Pfaff Nash Angela Zhang Sophie Waimon Tara J. Cepon-Robins |
| author_sort | Theresa E. Gildner |
| collection | DOAJ |
| description | Background Rising global obesity rates are linked with inflammation and associated morbidities. These negative outcomes are generally more common in low-resource communities within high-income countries; however, it is unclear how frequent infectious disease exposures in these settings may influence the relationship between adiposity and inflammation.Aim We test associations between adiposity measures and distinct forms of inflammation among adults (n = 80) living in low-resource U.S. communities experiencing high levels of obesity and pathogen exposure.Subjects and methods Adiposity measures included BMI and percent body fat. Inflammation measures included systemic inflammation (C-reactive protein [CRP]) and localised intestinal inflammation (faecal calprotectin [FC]). The relationship between a condition characterised by elevated inflammation (Helicobacter pylori infection) and adiposity was also considered.Results Adiposity was not significantly related to FC concentration. However, both adiposity measures were positively related with odds of CRP elevation and H. pylori infection was associated with significantly lower adiposity measures (all p < 0.05).Conclusion For this disadvantaged U.S. sample, the association between adiposity and inflammation varies by the systemic/localised nature of inflammation and the likely underlying cause of inflammation. Defining these associations will improve understanding of how rising obesity rates shape long-term health inequities, with implications for more effective intervention design. |
| format | Article |
| id | doaj-art-2af8c7ac336f4620bda655cbdbbe7f55 |
| institution | Kabale University |
| issn | 0301-4460 1464-5033 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Human Biology |
| spelling | doaj-art-2af8c7ac336f4620bda655cbdbbe7f552024-12-26T09:21:17ZengTaylor & Francis GroupAnnals of Human Biology0301-44601464-50332024-12-0151110.1080/03014460.2024.2368851Dual burden of infectious and chronic disease in low-resource U.S. communities: examining relationships between infection, adiposity, and inflammationTheresa E. Gildner0Samuel S. Urlacher1Katherine L. Nemeth2Jade A. Beauregard3Marcela Pfaff Nash4Angela Zhang5Sophie Waimon6Tara J. Cepon-Robins7Department of Anthropology, Washington University in St. Louis, St. Louis, MO, USADepartment of Anthropology, Baylor University, Waco, TX, USADepartment of Anthropology, Washington University in St. Louis, St. Louis, MO, USADepartment of Anthropology, Washington University in St. Louis, St. Louis, MO, USADepartment of Anthropology, Baylor University, Waco, TX, USADepartment of Anthropology, Washington University in St. Louis, St. Louis, MO, USADepartment of Anthropology, Washington University in St. Louis, St. Louis, MO, USADepartment of Anthropology, University of Colorado Colorado Springs, Colorado Springs, CO, USABackground Rising global obesity rates are linked with inflammation and associated morbidities. These negative outcomes are generally more common in low-resource communities within high-income countries; however, it is unclear how frequent infectious disease exposures in these settings may influence the relationship between adiposity and inflammation.Aim We test associations between adiposity measures and distinct forms of inflammation among adults (n = 80) living in low-resource U.S. communities experiencing high levels of obesity and pathogen exposure.Subjects and methods Adiposity measures included BMI and percent body fat. Inflammation measures included systemic inflammation (C-reactive protein [CRP]) and localised intestinal inflammation (faecal calprotectin [FC]). The relationship between a condition characterised by elevated inflammation (Helicobacter pylori infection) and adiposity was also considered.Results Adiposity was not significantly related to FC concentration. However, both adiposity measures were positively related with odds of CRP elevation and H. pylori infection was associated with significantly lower adiposity measures (all p < 0.05).Conclusion For this disadvantaged U.S. sample, the association between adiposity and inflammation varies by the systemic/localised nature of inflammation and the likely underlying cause of inflammation. Defining these associations will improve understanding of how rising obesity rates shape long-term health inequities, with implications for more effective intervention design.https://www.tandfonline.com/doi/10.1080/03014460.2024.2368851ObesityC-reactive proteinfaecal calprotectinHelicobacter pylori |
| spellingShingle | Theresa E. Gildner Samuel S. Urlacher Katherine L. Nemeth Jade A. Beauregard Marcela Pfaff Nash Angela Zhang Sophie Waimon Tara J. Cepon-Robins Dual burden of infectious and chronic disease in low-resource U.S. communities: examining relationships between infection, adiposity, and inflammation Annals of Human Biology Obesity C-reactive protein faecal calprotectin Helicobacter pylori |
| title | Dual burden of infectious and chronic disease in low-resource U.S. communities: examining relationships between infection, adiposity, and inflammation |
| title_full | Dual burden of infectious and chronic disease in low-resource U.S. communities: examining relationships between infection, adiposity, and inflammation |
| title_fullStr | Dual burden of infectious and chronic disease in low-resource U.S. communities: examining relationships between infection, adiposity, and inflammation |
| title_full_unstemmed | Dual burden of infectious and chronic disease in low-resource U.S. communities: examining relationships between infection, adiposity, and inflammation |
| title_short | Dual burden of infectious and chronic disease in low-resource U.S. communities: examining relationships between infection, adiposity, and inflammation |
| title_sort | dual burden of infectious and chronic disease in low resource u s communities examining relationships between infection adiposity and inflammation |
| topic | Obesity C-reactive protein faecal calprotectin Helicobacter pylori |
| url | https://www.tandfonline.com/doi/10.1080/03014460.2024.2368851 |
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