Prevalence of bone destruction in patients with TALAROMYCES MARNEFFEI infection: A systematic review and meta-analysis
Objectives: This systematic review and meta-analysis aimed to evaluate the prevalence of bone destruction in patients with Talaromyces marneffei infection, examine distribution patterns of bone lesions, and assess differences between HIV-positive and HIV-negative patients. Methods: Following PRISMA...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S120197122400434X |
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| _version_ | 1841560543207358464 |
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| author | Junhong Zhou Deshuang Xi Yilin Teng Shaohui Zong Gaofeng Zeng |
| author_facet | Junhong Zhou Deshuang Xi Yilin Teng Shaohui Zong Gaofeng Zeng |
| author_sort | Junhong Zhou |
| collection | DOAJ |
| description | Objectives: This systematic review and meta-analysis aimed to evaluate the prevalence of bone destruction in patients with Talaromyces marneffei infection, examine distribution patterns of bone lesions, and assess differences between HIV-positive and HIV-negative patients. Methods: Following PRISMA guidelines, 15 studies involving 839 patients were analyzed. Random-effects meta-analysis was performed to estimate prevalence and odds ratios. Study quality was assessed using ROBINS-I. Results: The overall prevalence of bone destruction was 18% (95% CI: 10-27%). HIV-negative patients showed significantly higher odds of bone destruction (OR: 0.09, 95% CI: 0.02-0.37%). Bone lesions were widely distributed, with osseous involvement (45.7-71.4%) more prevalent than articular (7.1-66.7%). The skull, ribs, and lumbar vertebrae were commonly affected. Conclusion: Bone destruction is a significant complication in TM infection, particularly in HIV-negative patients. The diverse anatomical distribution emphasizes the need for comprehensive skeletal assessment in suspected cases. |
| format | Article |
| id | doaj-art-2ab2c4bca29e43e985edc6f8d846ef87 |
| institution | Kabale University |
| issn | 1201-9712 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj-art-2ab2c4bca29e43e985edc6f8d846ef872025-01-04T04:56:03ZengElsevierInternational Journal of Infectious Diseases1201-97122025-02-01151107359Prevalence of bone destruction in patients with TALAROMYCES MARNEFFEI infection: A systematic review and meta-analysisJunhong Zhou0Deshuang Xi1Yilin Teng2Shaohui Zong3Gaofeng Zeng4Department of Spine and Osteopathy Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Spine and Osteopathy Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Spine and Osteopathy Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Spine and Osteopathy Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China; Department of Orthopedics, Wuming Hospital of Guangxi Medical University, Nanning, Guangxi, China; Correspondence: Shaohui Zong, Department of Spine and Osteopathy Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ChinaCollege of Public Hygiene of Guangxi Medical University, Nanning, Guangxi, ChinaObjectives: This systematic review and meta-analysis aimed to evaluate the prevalence of bone destruction in patients with Talaromyces marneffei infection, examine distribution patterns of bone lesions, and assess differences between HIV-positive and HIV-negative patients. Methods: Following PRISMA guidelines, 15 studies involving 839 patients were analyzed. Random-effects meta-analysis was performed to estimate prevalence and odds ratios. Study quality was assessed using ROBINS-I. Results: The overall prevalence of bone destruction was 18% (95% CI: 10-27%). HIV-negative patients showed significantly higher odds of bone destruction (OR: 0.09, 95% CI: 0.02-0.37%). Bone lesions were widely distributed, with osseous involvement (45.7-71.4%) more prevalent than articular (7.1-66.7%). The skull, ribs, and lumbar vertebrae were commonly affected. Conclusion: Bone destruction is a significant complication in TM infection, particularly in HIV-negative patients. The diverse anatomical distribution emphasizes the need for comprehensive skeletal assessment in suspected cases.http://www.sciencedirect.com/science/article/pii/S120197122400434XTalaromyces marneffeiBone destructionMeta-analysisPrevalenceHIV |
| spellingShingle | Junhong Zhou Deshuang Xi Yilin Teng Shaohui Zong Gaofeng Zeng Prevalence of bone destruction in patients with TALAROMYCES MARNEFFEI infection: A systematic review and meta-analysis International Journal of Infectious Diseases Talaromyces marneffei Bone destruction Meta-analysis Prevalence HIV |
| title | Prevalence of bone destruction in patients with TALAROMYCES MARNEFFEI infection: A systematic review and meta-analysis |
| title_full | Prevalence of bone destruction in patients with TALAROMYCES MARNEFFEI infection: A systematic review and meta-analysis |
| title_fullStr | Prevalence of bone destruction in patients with TALAROMYCES MARNEFFEI infection: A systematic review and meta-analysis |
| title_full_unstemmed | Prevalence of bone destruction in patients with TALAROMYCES MARNEFFEI infection: A systematic review and meta-analysis |
| title_short | Prevalence of bone destruction in patients with TALAROMYCES MARNEFFEI infection: A systematic review and meta-analysis |
| title_sort | prevalence of bone destruction in patients with talaromyces marneffei infection a systematic review and meta analysis |
| topic | Talaromyces marneffei Bone destruction Meta-analysis Prevalence HIV |
| url | http://www.sciencedirect.com/science/article/pii/S120197122400434X |
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