SARS-CoV-2 subvariant XEC: emerging challenges amidst the global decline of KP.3.1.1

Abstract The ongoing COVID-19 pandemic has seen the emergence of numerous SARS-CoV-2 variants, each posing distinct public health challenges. The XEC variant, a recombinant Omicron subvariant, has rapidly gained prevalence globally, raising critical questions about its potential implications on heal...

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Main Authors: Seun Adegboyega Adejumo, Henry Chukwuma, Onyeka Chukwudalu Ekwebene
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Research Notes
Online Access:https://doi.org/10.1186/s13104-025-07371-4
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author Seun Adegboyega Adejumo
Henry Chukwuma
Onyeka Chukwudalu Ekwebene
author_facet Seun Adegboyega Adejumo
Henry Chukwuma
Onyeka Chukwudalu Ekwebene
author_sort Seun Adegboyega Adejumo
collection DOAJ
description Abstract The ongoing COVID-19 pandemic has seen the emergence of numerous SARS-CoV-2 variants, each posing distinct public health challenges. The XEC variant, a recombinant Omicron subvariant, has rapidly gained prevalence globally, raising critical questions about its potential implications on health systems and public policy. This paper examines the emergence, spread, and unique characteristics of XEC, especially in the context of the global decline of KP.3.1.1, another significant Omicron lineage. We discussed the public health implications, including vaccine effectiveness, genomic surveillance, and healthcare system preparedness, underscoring the need for adaptive strategies in response to evolving SARS-CoV-2 variants.
format Article
id doaj-art-2a8a0f60daf94e249547e90c2ec24f1b
institution Kabale University
issn 1756-0500
language English
publishDate 2025-07-01
publisher BMC
record_format Article
series BMC Research Notes
spelling doaj-art-2a8a0f60daf94e249547e90c2ec24f1b2025-08-20T03:42:34ZengBMCBMC Research Notes1756-05002025-07-011811610.1186/s13104-025-07371-4SARS-CoV-2 subvariant XEC: emerging challenges amidst the global decline of KP.3.1.1Seun Adegboyega Adejumo0Henry Chukwuma1Onyeka Chukwudalu Ekwebene2School of Public Health Sciences, University of WaterlooSchool of Statistics, University of MinnesotaDepartment of Medicine and Surgery, Nnamdi Azikiwe UniversityAbstract The ongoing COVID-19 pandemic has seen the emergence of numerous SARS-CoV-2 variants, each posing distinct public health challenges. The XEC variant, a recombinant Omicron subvariant, has rapidly gained prevalence globally, raising critical questions about its potential implications on health systems and public policy. This paper examines the emergence, spread, and unique characteristics of XEC, especially in the context of the global decline of KP.3.1.1, another significant Omicron lineage. We discussed the public health implications, including vaccine effectiveness, genomic surveillance, and healthcare system preparedness, underscoring the need for adaptive strategies in response to evolving SARS-CoV-2 variants.https://doi.org/10.1186/s13104-025-07371-4
spellingShingle Seun Adegboyega Adejumo
Henry Chukwuma
Onyeka Chukwudalu Ekwebene
SARS-CoV-2 subvariant XEC: emerging challenges amidst the global decline of KP.3.1.1
BMC Research Notes
title SARS-CoV-2 subvariant XEC: emerging challenges amidst the global decline of KP.3.1.1
title_full SARS-CoV-2 subvariant XEC: emerging challenges amidst the global decline of KP.3.1.1
title_fullStr SARS-CoV-2 subvariant XEC: emerging challenges amidst the global decline of KP.3.1.1
title_full_unstemmed SARS-CoV-2 subvariant XEC: emerging challenges amidst the global decline of KP.3.1.1
title_short SARS-CoV-2 subvariant XEC: emerging challenges amidst the global decline of KP.3.1.1
title_sort sars cov 2 subvariant xec emerging challenges amidst the global decline of kp 3 1 1
url https://doi.org/10.1186/s13104-025-07371-4
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AT henrychukwuma sarscov2subvariantxecemergingchallengesamidsttheglobaldeclineofkp311
AT onyekachukwudaluekwebene sarscov2subvariantxecemergingchallengesamidsttheglobaldeclineofkp311