Co-immunization with spike and nucleocapsid based DNA vaccines for long-term protective immunity against SARS-CoV-2 Omicron

Co-immunization with spike and nucleocapsid based DNA vaccines for long-term protective immunity against SARS-CoV-2 Omicron

Abstract The continuing evolution of SARS-CoV-2 variants challenges the durability of existing spike (S)-based COVID-19 vaccines. We hypothesized that vaccines composed of both S and nucleocapsid (N) antigens would increase the durability of protection by strengthening and broadening cellular immuni...

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Bibliographic Details
Main Authors: Paolla Beatriz Almeida Pinto, Julia Timis, Kantinan Chuensirikulchai, Qin Hui Li, Hsueh Han Lu, Erin Maule, Michael Nguyen, Rúbens Prince dos Santos Alves, Shailendra Kumar Verma, Fernanda Ana-Sosa-Batiz, Kristen Valentine, Sara Landeras-Bueno, Kenneth Kim, Kathryn Hastie, Erica Ollmann Saphire, Ada Alves, Annie Elong Ngono, Sujan Shresta
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-024-01043-3
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