Polymorphisms in the CIITA −168A/G (rs3087456) and CIITA +1614G/C (rs4774) may influence severity in multiple sclerosis patients

Polymorphisms in the CIITA −168A/G (rs3087456) and CIITA +1614G/C (rs4774) may influence severity in multiple sclerosis patients

ABSTRACT It is currently unknown how genetic factors may influence the clinical course of multiple sclerosis (MS). Objective: We examined the impact of CIITA polymorphisms −168A/G (rs3087456) and +1614G/C (rs4774) on the risk of disability progression, severity and on responses to first-line immuno...

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Main Authors: Valéria Coelho Santa Rita Pereira, Fabrícia Lima Fontes-Dantas, Eduardo Ribeiro Paradela, Fabíola Rachid Malfetano, Simone de Souza Batista Scherpenhuijzen, Letícia Fêzer Mansur, Ronir Raggio Luiz, André Peres De Oliveira, João Gabriel Dib Farinhas, Ângelo Maiolino, Soniza Vieira Alves-Leon
Format: Article
Language:English
Published: Thieme Revinter Publicações
Series:Arquivos de Neuro-Psiquiatria
Subjects:
Multiple sclerosis
Polymorphism, Genetic
Therapeutics
Disease progression
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2019000300166&lng=en&tlng=en
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