Huangkui capsule combined with finerenone attenuates diabetic nephropathy by regulating the JAK2/STAT3 signaling pathway based on network pharmacology, molecular docking, and experimental verification

Huangkui capsule combined with finerenone attenuates diabetic nephropathy by regulating the JAK2/STAT3 signaling pathway based on network pharmacology, molecular docking, and experimental verification

IntroductionDiabetic nephropathy (DN) is a serious complication of diabetes with limited therapeutic options. Although Huangkui capsule (HKC) and finerenone individually show potential in DN management, their combined mechanism remains unclear. This study aimed to explore the therapeutic effects and...

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Bibliographic Details
Main Authors:	Xuanke Liu, Chunjiang Zhang, YanJie Fu, JingJing Dai, Jiaying Lu, Gang Liu, Xiaoping Yang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Series:	Frontiers in Pharmacology
Subjects:	finerenone diabetic nephropathy JAK2/STAT3 signaling pathway network pharmacology molecular docking kinetic simulation
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1625286/full
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