GPCR kinases phosphorylate GPCR C-terminal peptides in a hierarchical manner

GPCR kinases phosphorylate GPCR C-terminal peptides in a hierarchical manner

Abstract Responses from G protein-coupled receptors (GPCRs) are downregulated in a precisely orchestrated process called desensitization. This process consists of two major steps: phosphorylation of the receptor by GPCR kinases (GRKs), predominantly on its C-terminus, and recruitment of arrestin, re...

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Bibliographic Details
Main Authors: Arnelle Löbbert, Nils Lorz, Edda S. F. Matthees, Philip Rößler, Carsten Hoffmann, Alvar D. Gossert
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08301-7
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