Endovascular thrombectomy: an effective and safe therapy for perioperative ischemic stroke
BackgroundPerioperative ischemic stroke is a rare but devastating complication. Mechanical thrombectomy is a promising therapeutic method, but very little data is available on its efficacy and safety. This study aims to answer this question by comparing the clinical outcomes of perioperative and com...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1489296/full |
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| author | Feng Wang Xiaoping Xu Lin Zheng Jiawei Zhong En Wang Yang Liu Yang Liu Shaofa Ke |
| author_facet | Feng Wang Xiaoping Xu Lin Zheng Jiawei Zhong En Wang Yang Liu Yang Liu Shaofa Ke |
| author_sort | Feng Wang |
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| description | BackgroundPerioperative ischemic stroke is a rare but devastating complication. Mechanical thrombectomy is a promising therapeutic method, but very little data is available on its efficacy and safety. This study aims to answer this question by comparing the clinical outcomes of perioperative and community-onset stroke patients after endovascular therapy.MethodsA retrospective cohort study was conducted on a total of 35 perioperative and 584 community-onset acute ischemic stroke patients who underwent endovascular thrombectomy at our hospital over the past 3.5 years. The recanalization rate, clinical recovery and cerebral hemorrhage within 90 days after therapy were compared between these two patient groups.ResultsEndovascular thrombectomy provided perioperative and community-onset ischemic stroke patients with comparable rates of successful reperfusion (mTICI ≥2b grade) (97.1% vs. 97.3%; p = 0. 967) and favorable functional recovery (mRS ≤ 2) (51.4% vs. 43.3%, p = 0.348), with no increase in severe intracranial hemorrhage (0% vs. 2.6 and 1.0%, for hematoma ≥30% of infarcted tissue and intraventricular hemorrhage, respectively) within 90 days. In addition, perioperative stroke patients had higher prevalence of atrial fibrillation (42.9% vs. 26.7%; p = 0.038) and intracranial cerebral artery stenosis without clear embolism (17.1% vs. 3.8%; p < 0.001) than community-onset stroke patients.ConclusionEndovascular thrombectomy is an effective and safe therapeutic approach for patients with perioperative ischemic stroke, although the results need to be validated by further studies with larger populations. Atrial fibrillation and large artery stenosis may contribute to the pathogenesis of perioperative ischemic stroke. |
| format | Article |
| id | doaj-art-2a61d0ffa2d8472695f3ae3e5b383014 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-2a61d0ffa2d8472695f3ae3e5b3830142024-12-02T09:14:37ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-11-011510.3389/fneur.2024.14892961489296Endovascular thrombectomy: an effective and safe therapy for perioperative ischemic strokeFeng Wang0Xiaoping Xu1Lin Zheng2Jiawei Zhong3En Wang4Yang Liu5Yang Liu6Shaofa Ke7Department of Neurology, Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University, Linhai, Zhejiang, ChinaDepartment of Neurology, Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University, Linhai, Zhejiang, ChinaDepartment of Neurology, Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University, Linhai, Zhejiang, ChinaDepartment of Neurology, Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University, Linhai, Zhejiang, ChinaDepartment of Neurology, Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University, Linhai, Zhejiang, ChinaDepartment of Neurology, Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University, Linhai, Zhejiang, ChinaDepartment of Neurology, Saarland University, Homburg, GermanyDepartment of Neurology, Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University, Linhai, Zhejiang, ChinaBackgroundPerioperative ischemic stroke is a rare but devastating complication. Mechanical thrombectomy is a promising therapeutic method, but very little data is available on its efficacy and safety. This study aims to answer this question by comparing the clinical outcomes of perioperative and community-onset stroke patients after endovascular therapy.MethodsA retrospective cohort study was conducted on a total of 35 perioperative and 584 community-onset acute ischemic stroke patients who underwent endovascular thrombectomy at our hospital over the past 3.5 years. The recanalization rate, clinical recovery and cerebral hemorrhage within 90 days after therapy were compared between these two patient groups.ResultsEndovascular thrombectomy provided perioperative and community-onset ischemic stroke patients with comparable rates of successful reperfusion (mTICI ≥2b grade) (97.1% vs. 97.3%; p = 0. 967) and favorable functional recovery (mRS ≤ 2) (51.4% vs. 43.3%, p = 0.348), with no increase in severe intracranial hemorrhage (0% vs. 2.6 and 1.0%, for hematoma ≥30% of infarcted tissue and intraventricular hemorrhage, respectively) within 90 days. In addition, perioperative stroke patients had higher prevalence of atrial fibrillation (42.9% vs. 26.7%; p = 0.038) and intracranial cerebral artery stenosis without clear embolism (17.1% vs. 3.8%; p < 0.001) than community-onset stroke patients.ConclusionEndovascular thrombectomy is an effective and safe therapeutic approach for patients with perioperative ischemic stroke, although the results need to be validated by further studies with larger populations. Atrial fibrillation and large artery stenosis may contribute to the pathogenesis of perioperative ischemic stroke.https://www.frontiersin.org/articles/10.3389/fneur.2024.1489296/fullperioperative strokecommunity-onset strokeendovascular thrombectomyintracranial hemorrhageprognosis |
| spellingShingle | Feng Wang Xiaoping Xu Lin Zheng Jiawei Zhong En Wang Yang Liu Yang Liu Shaofa Ke Endovascular thrombectomy: an effective and safe therapy for perioperative ischemic stroke Frontiers in Neurology perioperative stroke community-onset stroke endovascular thrombectomy intracranial hemorrhage prognosis |
| title | Endovascular thrombectomy: an effective and safe therapy for perioperative ischemic stroke |
| title_full | Endovascular thrombectomy: an effective and safe therapy for perioperative ischemic stroke |
| title_fullStr | Endovascular thrombectomy: an effective and safe therapy for perioperative ischemic stroke |
| title_full_unstemmed | Endovascular thrombectomy: an effective and safe therapy for perioperative ischemic stroke |
| title_short | Endovascular thrombectomy: an effective and safe therapy for perioperative ischemic stroke |
| title_sort | endovascular thrombectomy an effective and safe therapy for perioperative ischemic stroke |
| topic | perioperative stroke community-onset stroke endovascular thrombectomy intracranial hemorrhage prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1489296/full |
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