Lyme Neuroborreliosis: Preliminary Results from an Urban Referral Center Employing Strict CDC Criteria for Case Selection
Lyme neuroborreliosis or “neurological Lyme disease” was evidenced in 2 of 23 patients submitted to strict criteria for case selection of the Centers for Disease Control and Prevention employing a two-tier test to detect...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2010/525206 |
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| _version_ | 1841524840346943488 |
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| author | David S. Younger Stuart Orsher |
| author_facet | David S. Younger Stuart Orsher |
| author_sort | David S. Younger |
| collection | DOAJ |
| description | Lyme neuroborreliosis
or “neurological Lyme disease” was
evidenced in 2 of 23 patients submitted to strict criteria for case
selection of the Centers for Disease Control and
Prevention employing a two-tier test to detect
antibodies to Borrelia
burgdorferi at a single institution.
One patient had symptomatic
polyradiculoneuritis, dysautonomia, and
serological evidence of early infection; and
another had symptomatic small fiber sensory
neuropathy, distal polyneuropathy,
dysautonomia, and serological evidence of late
infection. In the remaining patients symptoms
initially ascribed to Lyme disease were probably
unrelated to B. burgdorferi
infection. Our findings suggest early
susceptibility and protracted involvement of the
nervous system most likely due to the
immunological effects of B.
burgdorferi infection, although the
exact mechanisms remain uncertain. |
| format | Article |
| id | doaj-art-2a5b58bc974a44ba9592181a5ecf5eda |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-2a5b58bc974a44ba9592181a5ecf5eda2025-02-03T05:47:10ZengWileyNeurology Research International2090-18522090-18602010-01-01201010.1155/2010/525206525206Lyme Neuroborreliosis: Preliminary Results from an Urban Referral Center Employing Strict CDC Criteria for Case SelectionDavid S. Younger0Stuart Orsher1Lyme Neuroborreliosis Research Program, NYU School of Medicine, 333 East 34th Street, Suite 1J, NY 10016, USADepartment of Medicine, Lenox Hill Hospital, New York, NY 10021, USALyme neuroborreliosis or “neurological Lyme disease” was evidenced in 2 of 23 patients submitted to strict criteria for case selection of the Centers for Disease Control and Prevention employing a two-tier test to detect antibodies to Borrelia burgdorferi at a single institution. One patient had symptomatic polyradiculoneuritis, dysautonomia, and serological evidence of early infection; and another had symptomatic small fiber sensory neuropathy, distal polyneuropathy, dysautonomia, and serological evidence of late infection. In the remaining patients symptoms initially ascribed to Lyme disease were probably unrelated to B. burgdorferi infection. Our findings suggest early susceptibility and protracted involvement of the nervous system most likely due to the immunological effects of B. burgdorferi infection, although the exact mechanisms remain uncertain.http://dx.doi.org/10.1155/2010/525206 |
| spellingShingle | David S. Younger Stuart Orsher Lyme Neuroborreliosis: Preliminary Results from an Urban Referral Center Employing Strict CDC Criteria for Case Selection Neurology Research International |
| title | Lyme Neuroborreliosis: Preliminary Results from an Urban Referral Center Employing Strict CDC Criteria for Case Selection |
| title_full | Lyme Neuroborreliosis: Preliminary Results from an Urban Referral Center Employing Strict CDC Criteria for Case Selection |
| title_fullStr | Lyme Neuroborreliosis: Preliminary Results from an Urban Referral Center Employing Strict CDC Criteria for Case Selection |
| title_full_unstemmed | Lyme Neuroborreliosis: Preliminary Results from an Urban Referral Center Employing Strict CDC Criteria for Case Selection |
| title_short | Lyme Neuroborreliosis: Preliminary Results from an Urban Referral Center Employing Strict CDC Criteria for Case Selection |
| title_sort | lyme neuroborreliosis preliminary results from an urban referral center employing strict cdc criteria for case selection |
| url | http://dx.doi.org/10.1155/2010/525206 |
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