Does the Systemic Immune Inflammation Index and Plasma Atherogenic Index Predict Poor Prognosis in Patients Undergoing Mitral Balloon Valvuloplasty?
Objective: In this study, we aimed to investigate the impact of the systemic immune-inflammation index (SII) and plasma atherogenic index (PAI) on adverse outcomes in patients undergoing percutaneous mitral balloon valvuloplasty (PMBV). A 5-year follow-up was conducted in patients with mitral stenos...
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Galenos Publishing House
2024-07-01
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| Series: | Gazi Medical Journal |
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| Online Access: | https://gazimedj.com/articles/does-the-systemic-immune-inflammation-index-and-plasma-atherogenic-index-predict-poor-prognosis-in-patients-undergoing-mitral-balloon-valvuloplasty/doi/gmj.2024.4007 |
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| author | Nergiz Aydın Sefa Tatar Ahmet Taha Şahin Yakup Alsancak |
| author_facet | Nergiz Aydın Sefa Tatar Ahmet Taha Şahin Yakup Alsancak |
| author_sort | Nergiz Aydın |
| collection | DOAJ |
| description | Objective: In this study, we aimed to investigate the impact of the systemic immune-inflammation index (SII) and plasma atherogenic index (PAI) on adverse outcomes in patients undergoing percutaneous mitral balloon valvuloplasty (PMBV). A 5-year follow-up was conducted in patients with mitral stenosis who underwent PMBV, assessing all-cause mortality, major adverse cardiovascular events (MACE), surgical need for the mitral valve, and requirement for repeat PMBV.
Methods: This single-center retrospective study included 103 patients who underwent PMBV due to rheumatic mitral valve disease between January 2014 and January 2019. Demographic characteristics and pre- and postprocedural echocardiographic data of the patients were analyzed. The 5-year follow-up included assessments of all-cause mortality, MACE, surgical requirement for the mitral valve, and rates of repeat PMBV. Laboratory parameters at admission and at the third-month follow-up were recorded through a review of patient records.
Results: A total of 103 patients (75 females) with a mean age of 41.81±14.83 years were enrolled in the study. At admission, the SII was calculated as 8.49±6.27, PAI as 0.45±0.25, and the mitral valve area (MVA) as 1.16±0.19 cm2. Post-procedurally, MVA increased to 1.72±0.23 (p=0.001). At the third-month follow-up, SII was 7.77±7.16, and PAI was 0.47±0.25. While a statistically significant decrease was observed in SII post-procedure (p<0.001), no significant change was noted in PAI (p=0.843). When examining 5-year MACE rates in the deceased group, the SII at admission was 765.5±577.3, and at the third month, it was 794.2±907.6 (p>0.05). Regarding 5-year MACE rates in the deceased group, the PAI value at admission was 0.4±0.41, and at the third month, it was 0.4±0.42 (p>0.05).
Conclusion: In patients undergoing PMBV, SII is a significant parameter indicating a reduction in inflammation. However, both SII and PAI are insufficient for predicting the 5-year MACE frequency after PMBV. Additional parameters are required to indicate poor prognosis. |
| format | Article |
| id | doaj-art-2a4821bc176a4a5cbdf847ce43da5201 |
| institution | Kabale University |
| issn | 2147-2092 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Galenos Publishing House |
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| series | Gazi Medical Journal |
| spelling | doaj-art-2a4821bc176a4a5cbdf847ce43da52012025-01-16T14:13:26ZengGalenos Publishing HouseGazi Medical Journal2147-20922024-07-0135331031410.12996/gmj.2024.4007Does the Systemic Immune Inflammation Index and Plasma Atherogenic Index Predict Poor Prognosis in Patients Undergoing Mitral Balloon Valvuloplasty?Nergiz Aydın0https://orcid.org/0000-0002-2928-1059Sefa Tatar1https://orcid.org/0000-0001-8703-5078Ahmet Taha Şahin2https://orcid.org/0000-0002-2928-1059Yakup Alsancak3https://orcid.org/0000-0001-5230-2180Department of Cardiology Necmettin Erbakan University, Meram Faculty of Medicine, Konya, TürkiyeDepartment of Cardiology Necmettin Erbakan University, Meram Faculty of Medicine, Konya, TürkiyeDepartment of Cardiology Necmettin Erbakan University, Meram Faculty of Medicine, Konya, TürkiyeDepartment of Cardiology Necmettin Erbakan University, Meram Faculty of Medicine, Konya, TürkiyeObjective: In this study, we aimed to investigate the impact of the systemic immune-inflammation index (SII) and plasma atherogenic index (PAI) on adverse outcomes in patients undergoing percutaneous mitral balloon valvuloplasty (PMBV). A 5-year follow-up was conducted in patients with mitral stenosis who underwent PMBV, assessing all-cause mortality, major adverse cardiovascular events (MACE), surgical need for the mitral valve, and requirement for repeat PMBV. Methods: This single-center retrospective study included 103 patients who underwent PMBV due to rheumatic mitral valve disease between January 2014 and January 2019. Demographic characteristics and pre- and postprocedural echocardiographic data of the patients were analyzed. The 5-year follow-up included assessments of all-cause mortality, MACE, surgical requirement for the mitral valve, and rates of repeat PMBV. Laboratory parameters at admission and at the third-month follow-up were recorded through a review of patient records. Results: A total of 103 patients (75 females) with a mean age of 41.81±14.83 years were enrolled in the study. At admission, the SII was calculated as 8.49±6.27, PAI as 0.45±0.25, and the mitral valve area (MVA) as 1.16±0.19 cm2. Post-procedurally, MVA increased to 1.72±0.23 (p=0.001). At the third-month follow-up, SII was 7.77±7.16, and PAI was 0.47±0.25. While a statistically significant decrease was observed in SII post-procedure (p<0.001), no significant change was noted in PAI (p=0.843). When examining 5-year MACE rates in the deceased group, the SII at admission was 765.5±577.3, and at the third month, it was 794.2±907.6 (p>0.05). Regarding 5-year MACE rates in the deceased group, the PAI value at admission was 0.4±0.41, and at the third month, it was 0.4±0.42 (p>0.05). Conclusion: In patients undergoing PMBV, SII is a significant parameter indicating a reduction in inflammation. However, both SII and PAI are insufficient for predicting the 5-year MACE frequency after PMBV. Additional parameters are required to indicate poor prognosis.https://gazimedj.com/articles/does-the-systemic-immune-inflammation-index-and-plasma-atherogenic-index-predict-poor-prognosis-in-patients-undergoing-mitral-balloon-valvuloplasty/doi/gmj.2024.4007percutaneous mitral balloon valvuloplastymitral valve stenosissystemic immune-inflammation indexplasma atherogenic indexmace |
| spellingShingle | Nergiz Aydın Sefa Tatar Ahmet Taha Şahin Yakup Alsancak Does the Systemic Immune Inflammation Index and Plasma Atherogenic Index Predict Poor Prognosis in Patients Undergoing Mitral Balloon Valvuloplasty? Gazi Medical Journal percutaneous mitral balloon valvuloplasty mitral valve stenosis systemic immune-inflammation index plasma atherogenic index mace |
| title | Does the Systemic Immune Inflammation Index and Plasma Atherogenic Index Predict Poor Prognosis in Patients Undergoing Mitral Balloon Valvuloplasty? |
| title_full | Does the Systemic Immune Inflammation Index and Plasma Atherogenic Index Predict Poor Prognosis in Patients Undergoing Mitral Balloon Valvuloplasty? |
| title_fullStr | Does the Systemic Immune Inflammation Index and Plasma Atherogenic Index Predict Poor Prognosis in Patients Undergoing Mitral Balloon Valvuloplasty? |
| title_full_unstemmed | Does the Systemic Immune Inflammation Index and Plasma Atherogenic Index Predict Poor Prognosis in Patients Undergoing Mitral Balloon Valvuloplasty? |
| title_short | Does the Systemic Immune Inflammation Index and Plasma Atherogenic Index Predict Poor Prognosis in Patients Undergoing Mitral Balloon Valvuloplasty? |
| title_sort | does the systemic immune inflammation index and plasma atherogenic index predict poor prognosis in patients undergoing mitral balloon valvuloplasty |
| topic | percutaneous mitral balloon valvuloplasty mitral valve stenosis systemic immune-inflammation index plasma atherogenic index mace |
| url | https://gazimedj.com/articles/does-the-systemic-immune-inflammation-index-and-plasma-atherogenic-index-predict-poor-prognosis-in-patients-undergoing-mitral-balloon-valvuloplasty/doi/gmj.2024.4007 |
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