Efficient delivery of small RNAs to podocytes in vitro by direct exosome transfection

Efficient delivery of small RNAs to podocytes in vitro by direct exosome transfection

Abstract Background Podocytes are a crucial component of the glomerular filtration barrier, and changes in their 3D structure contribute to over 80% of chronic kidney disease (CKD) cases. Exosomal small RNAs play a key role in cell–cell communication in CKD and may serve as nanocarriers for deliveri...

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Bibliographic Details
Main Authors: Tim Lange, Luzia Maron, Claudia Weber, Doreen Biedenweg, Rabea Schlüter, Nicole Endlich
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Nanobiotechnology
Subjects:
Podocyte
Exosomes
Transfection
Vesicles
CKD
Small RNA
Online Access:https://doi.org/10.1186/s12951-025-03426-7
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