Effects of host modulation through omega-3 dietary supplementation on inflammatory outcomes in periodontitis: a scoping review
ABSTRACT Objective: Inflammation causes the progressive destruction of the supporting tissues around teeth in patients with periodontitis. Therefore, this study aimed to investigate the immunological effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) as adjunctive therapy in patients with p...
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
2024-12-01
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| author | Aline Ramos Carlucci Beatriz Rezende Bergo Rafael Nascimento de Brito Silva Gabriella de Deus Bressane Mauricio Baeza Nídia Castro dos Santos |
| author_facet | Aline Ramos Carlucci Beatriz Rezende Bergo Rafael Nascimento de Brito Silva Gabriella de Deus Bressane Mauricio Baeza Nídia Castro dos Santos |
| author_sort | Aline Ramos Carlucci |
| collection | DOAJ |
| description | ABSTRACT Objective: Inflammation causes the progressive destruction of the supporting tissues around teeth in patients with periodontitis. Therefore, this study aimed to investigate the immunological effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) as adjunctive therapy in patients with periodontal disease and identify potential biomarkers for the disease. Methods: This scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to investigate the impact of omega-3 therapy with or without acetylsalicylic acid on the immunological parameters of periodontal treatment. Eligible studies included those conducted on patients with normoglycemia and diabetes, published after 2002 in English, and containing relevant keywords. The exclusion criteria included pre-2002 publications, literature reviews, animal studies, and articles without immunological analysis. This review involved careful study selection by two double-blind researchers using the Rayyan software, with data extraction and analysis performed by the third and fourth reviewers. Results: Seven randomized clinical trials that compared control/placebo and n-3 PUFA groups or the follow-ups of the n-3 PUFA groups were included. The concentration of inflammatory cytokines was reduced following dietary supplementation with n-3 PUFA in the reviewed studies. Specifically, IL-1β, TNF-α, IL-6, and RANKL levels were reduced after dietary supplementation with n-3 PUFA as an adjunctive therapy for periodontitis. Changes in inflammatory outcomes were associated with the clinical benefits of periodontitis. However, significant divergence in the evaluated inflammatory markers, samples, and methods impairs direct comparisons and quantitative analyses in the available literature. Conclusion: This study highlights the need for clinical trials to advance our understanding and assessment of inflammatory outcomes in patients with periodontitis. |
| format | Article |
| id | doaj-art-2a1340e5e9a941cbbe1dbeaea9ec8e76 |
| institution | Kabale University |
| issn | 2317-6385 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj-art-2a1340e5e9a941cbbe1dbeaea9ec8e762024-12-17T07:56:17ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-63852024-12-012210.31744/einstein_journal/2024rw0936Effects of host modulation through omega-3 dietary supplementation on inflammatory outcomes in periodontitis: a scoping reviewAline Ramos Carluccihttps://orcid.org/0000-0002-4411-1795Beatriz Rezende Bergohttps://orcid.org/0000-0002-7030-3440Rafael Nascimento de Brito Silvahttps://orcid.org/0000-0002-3863-7790Gabriella de Deus Bressanehttps://orcid.org/0000-0001-8341-2702Mauricio Baezahttps://orcid.org/0000-0001-8910-4700Nídia Castro dos Santoshttps://orcid.org/0000-0003-2041-9426ABSTRACT Objective: Inflammation causes the progressive destruction of the supporting tissues around teeth in patients with periodontitis. Therefore, this study aimed to investigate the immunological effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) as adjunctive therapy in patients with periodontal disease and identify potential biomarkers for the disease. Methods: This scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to investigate the impact of omega-3 therapy with or without acetylsalicylic acid on the immunological parameters of periodontal treatment. Eligible studies included those conducted on patients with normoglycemia and diabetes, published after 2002 in English, and containing relevant keywords. The exclusion criteria included pre-2002 publications, literature reviews, animal studies, and articles without immunological analysis. This review involved careful study selection by two double-blind researchers using the Rayyan software, with data extraction and analysis performed by the third and fourth reviewers. Results: Seven randomized clinical trials that compared control/placebo and n-3 PUFA groups or the follow-ups of the n-3 PUFA groups were included. The concentration of inflammatory cytokines was reduced following dietary supplementation with n-3 PUFA in the reviewed studies. Specifically, IL-1β, TNF-α, IL-6, and RANKL levels were reduced after dietary supplementation with n-3 PUFA as an adjunctive therapy for periodontitis. Changes in inflammatory outcomes were associated with the clinical benefits of periodontitis. However, significant divergence in the evaluated inflammatory markers, samples, and methods impairs direct comparisons and quantitative analyses in the available literature. Conclusion: This study highlights the need for clinical trials to advance our understanding and assessment of inflammatory outcomes in patients with periodontitis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082024000100413&lng=en&tlng=enCytokinesFatty acidsInflammationOmega-3Periodontitis |
| spellingShingle | Aline Ramos Carlucci Beatriz Rezende Bergo Rafael Nascimento de Brito Silva Gabriella de Deus Bressane Mauricio Baeza Nídia Castro dos Santos Effects of host modulation through omega-3 dietary supplementation on inflammatory outcomes in periodontitis: a scoping review Einstein (São Paulo) Cytokines Fatty acids Inflammation Omega-3 Periodontitis |
| title | Effects of host modulation through omega-3 dietary supplementation on inflammatory outcomes in periodontitis: a scoping review |
| title_full | Effects of host modulation through omega-3 dietary supplementation on inflammatory outcomes in periodontitis: a scoping review |
| title_fullStr | Effects of host modulation through omega-3 dietary supplementation on inflammatory outcomes in periodontitis: a scoping review |
| title_full_unstemmed | Effects of host modulation through omega-3 dietary supplementation on inflammatory outcomes in periodontitis: a scoping review |
| title_short | Effects of host modulation through omega-3 dietary supplementation on inflammatory outcomes in periodontitis: a scoping review |
| title_sort | effects of host modulation through omega 3 dietary supplementation on inflammatory outcomes in periodontitis a scoping review |
| topic | Cytokines Fatty acids Inflammation Omega-3 Periodontitis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082024000100413&lng=en&tlng=en |
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