Effects of Resveratrol on Adipocytes: Evidence from In Vitro and In Vivo Studies
Obesity, a prevalent global health issue, arises from an imbalance between caloric intake and energy expenditure, leading to the expansion of adipose tissue and metabolic dysfunction. White adipose tissue (WAT) stores energy as lipids, while brown adipose tissue (BAT) plays a pivotal role in energy...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/29/22/5359 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846152767967592448 |
|---|---|
| author | Matthew Terzo Michael Iantomasi Evangelia Tsiani |
| author_facet | Matthew Terzo Michael Iantomasi Evangelia Tsiani |
| author_sort | Matthew Terzo |
| collection | DOAJ |
| description | Obesity, a prevalent global health issue, arises from an imbalance between caloric intake and energy expenditure, leading to the expansion of adipose tissue and metabolic dysfunction. White adipose tissue (WAT) stores energy as lipids, while brown adipose tissue (BAT) plays a pivotal role in energy dissipation through adaptive thermogenesis. Recent research initiatives have focused on finding strategies to decrease adipogenesis and fat mass accumulation and increase thermogenesis. Finding chemicals with anti-obesity properties would be beneficial. Resveratrol, a polyphenolic compound abundantly found in the skin of grapes and red wine, possesses anti-oxidant, anti-inflammatory, anti-cancer, and anti-obesity properties. This literature review examines the effects of resveratrol on adipocytes in culture and adipose tissue in animal models of obesity. The existing evidence indicates that resveratrol may exert its anti-obesity effects by inhibiting adipogenesis, promoting the apoptosis of mature adipocytes, reducing lipid accumulation, and increasing thermogenesis. Further research utilizing animal and clinical studies is required to understand in detail the anti-obesity potential of resveratrol. |
| format | Article |
| id | doaj-art-2a0d7728dee04b69bc603d9d091f3904 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-2a0d7728dee04b69bc603d9d091f39042024-11-26T18:15:41ZengMDPI AGMolecules1420-30492024-11-012922535910.3390/molecules29225359Effects of Resveratrol on Adipocytes: Evidence from In Vitro and In Vivo StudiesMatthew Terzo0Michael Iantomasi1Evangelia Tsiani2Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, CanadaDepartment of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, CanadaDepartment of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, CanadaObesity, a prevalent global health issue, arises from an imbalance between caloric intake and energy expenditure, leading to the expansion of adipose tissue and metabolic dysfunction. White adipose tissue (WAT) stores energy as lipids, while brown adipose tissue (BAT) plays a pivotal role in energy dissipation through adaptive thermogenesis. Recent research initiatives have focused on finding strategies to decrease adipogenesis and fat mass accumulation and increase thermogenesis. Finding chemicals with anti-obesity properties would be beneficial. Resveratrol, a polyphenolic compound abundantly found in the skin of grapes and red wine, possesses anti-oxidant, anti-inflammatory, anti-cancer, and anti-obesity properties. This literature review examines the effects of resveratrol on adipocytes in culture and adipose tissue in animal models of obesity. The existing evidence indicates that resveratrol may exert its anti-obesity effects by inhibiting adipogenesis, promoting the apoptosis of mature adipocytes, reducing lipid accumulation, and increasing thermogenesis. Further research utilizing animal and clinical studies is required to understand in detail the anti-obesity potential of resveratrol.https://www.mdpi.com/1420-3049/29/22/5359obesityadipocytesadipose tissueresveratrol |
| spellingShingle | Matthew Terzo Michael Iantomasi Evangelia Tsiani Effects of Resveratrol on Adipocytes: Evidence from In Vitro and In Vivo Studies Molecules obesity adipocytes adipose tissue resveratrol |
| title | Effects of Resveratrol on Adipocytes: Evidence from In Vitro and In Vivo Studies |
| title_full | Effects of Resveratrol on Adipocytes: Evidence from In Vitro and In Vivo Studies |
| title_fullStr | Effects of Resveratrol on Adipocytes: Evidence from In Vitro and In Vivo Studies |
| title_full_unstemmed | Effects of Resveratrol on Adipocytes: Evidence from In Vitro and In Vivo Studies |
| title_short | Effects of Resveratrol on Adipocytes: Evidence from In Vitro and In Vivo Studies |
| title_sort | effects of resveratrol on adipocytes evidence from in vitro and in vivo studies |
| topic | obesity adipocytes adipose tissue resveratrol |
| url | https://www.mdpi.com/1420-3049/29/22/5359 |
| work_keys_str_mv | AT matthewterzo effectsofresveratrolonadipocytesevidencefrominvitroandinvivostudies AT michaeliantomasi effectsofresveratrolonadipocytesevidencefrominvitroandinvivostudies AT evangeliatsiani effectsofresveratrolonadipocytesevidencefrominvitroandinvivostudies |