A competitive protein interaction network buffers Oct4‐mediated differentiation to promote pluripotency in embryonic stem cells

A competitive protein interaction network buffers Oct4‐mediated differentiation to promote pluripotency in embryonic stem cells

Abstract Pluripotency in embryonic stem cells is maintained through the activity of a small set of transcription factors centred around Oct4 and Nanog, which control the expression of ‘self‐renewal’ and ‘differentiation’ genes. Here, we combine single‐cell quantitative immunofluorescence microscopy...

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Bibliographic Details
Main Authors: Silvia Muñoz Descalzo, Pau Rué, Fernando Faunes, Penelope Hayward, Lars Martin Jakt, Tina Balayo, Jordi Garcia‐Ojalvo, Alfonso Martinez Arias
Format: Article
Language:English
Published: Springer Nature 2013-10-01
Series:Molecular Systems Biology
Subjects:
β‐catenin
mathematical modelling
Oct4
pluripotency
protein network
Online Access:https://doi.org/10.1038/msb.2013.49
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https://doi.org/10.1038/msb.2013.49

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