Evaluating the weight-adjusted waist index as a predictive tool for sarcopenia and mortality risk
Abstract Purpose The weight-adjusted waist index (WWI) is a novel anthropometric measure. WWI is linked to reduced muscle mass and strength; however, its efficacy for assessing sarcopenia and predicting adverse outcomes has yet to be validated. This study compared and examined the relationship betwe...
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| Format: | Article |
| Language: | English |
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Springer
2025-01-01
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| Series: | Eating and Weight Disorders |
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| Online Access: | https://doi.org/10.1007/s40519-024-01712-1 |
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| author | Qingzheng Shen Tianjing Zhou Xiaodong Chen Hafiz Muhammad Umar Xinxin Yang Xian Shen |
| author_facet | Qingzheng Shen Tianjing Zhou Xiaodong Chen Hafiz Muhammad Umar Xinxin Yang Xian Shen |
| author_sort | Qingzheng Shen |
| collection | DOAJ |
| description | Abstract Purpose The weight-adjusted waist index (WWI) is a novel anthropometric measure. WWI is linked to reduced muscle mass and strength; however, its efficacy for assessing sarcopenia and predicting adverse outcomes has yet to be validated. This study compared and examined the relationship between sarcopenia and WWI across different diagnostic criteria and aimed to evaluate its potential as a predictor of sarcopenia and all-cause mortality. Methods This study used data from 2946 NHANES (1999–2002) participants to analyze the relationship between weight-adjusted waist index (WWI) and sarcopenia (diagnosed using five different established criteria). Multivariable logistic regression, ROC analysis, Kaplan–Meier curves, and Cox regression were used to assess the association between WWI and sarcopenia and mortality. Results WWI was inversely correlated with walking speed, muscle strength, and muscle mass. It served as a significant predictor of sarcopenia, particularly in men, with an area under the ROC curve (AUC) of 0.86 for men according to FNIH criteria. Furthermore, a higher mortality rate from all causes was linked to a higher WWI. The mortality rate among patients with sarcopenia, as predicted by the WWI and FNIH criteria, was higher than that of patients diagnosed by a single criterion. Conclusions WWI proves to be a valuable tool in predicting sarcopenia and mortality risk, particularly when using the FNIH criteria. However, its performance varied significantly across different criteria and populations. Further research is needed to define the specific clinical contexts where WWI may be a useful supplementary tool. Level of Evidence Level III, evidence obtained from a cohort analytic study. |
| format | Article |
| id | doaj-art-29f612f1e3c94573b4591bba86a1b538 |
| institution | Kabale University |
| issn | 1590-1262 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
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| series | Eating and Weight Disorders |
| spelling | doaj-art-29f612f1e3c94573b4591bba86a1b5382025-01-05T12:05:13ZengSpringerEating and Weight Disorders1590-12622025-01-0130111410.1007/s40519-024-01712-1Evaluating the weight-adjusted waist index as a predictive tool for sarcopenia and mortality riskQingzheng Shen0Tianjing Zhou1Xiaodong Chen2Hafiz Muhammad Umar3Xinxin Yang4Xian Shen5Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical UniversityDepartment of Dermatology, The Second Affiliated Hospital and Yuying Children‘s Hospital of Wenzhou Medical UniversityDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical UniversityDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical UniversityDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical UniversityDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical UniversityAbstract Purpose The weight-adjusted waist index (WWI) is a novel anthropometric measure. WWI is linked to reduced muscle mass and strength; however, its efficacy for assessing sarcopenia and predicting adverse outcomes has yet to be validated. This study compared and examined the relationship between sarcopenia and WWI across different diagnostic criteria and aimed to evaluate its potential as a predictor of sarcopenia and all-cause mortality. Methods This study used data from 2946 NHANES (1999–2002) participants to analyze the relationship between weight-adjusted waist index (WWI) and sarcopenia (diagnosed using five different established criteria). Multivariable logistic regression, ROC analysis, Kaplan–Meier curves, and Cox regression were used to assess the association between WWI and sarcopenia and mortality. Results WWI was inversely correlated with walking speed, muscle strength, and muscle mass. It served as a significant predictor of sarcopenia, particularly in men, with an area under the ROC curve (AUC) of 0.86 for men according to FNIH criteria. Furthermore, a higher mortality rate from all causes was linked to a higher WWI. The mortality rate among patients with sarcopenia, as predicted by the WWI and FNIH criteria, was higher than that of patients diagnosed by a single criterion. Conclusions WWI proves to be a valuable tool in predicting sarcopenia and mortality risk, particularly when using the FNIH criteria. However, its performance varied significantly across different criteria and populations. Further research is needed to define the specific clinical contexts where WWI may be a useful supplementary tool. Level of Evidence Level III, evidence obtained from a cohort analytic study.https://doi.org/10.1007/s40519-024-01712-1SarcopeniaWWIObesityAll-cause mortalityNHANESCross-sectional study |
| spellingShingle | Qingzheng Shen Tianjing Zhou Xiaodong Chen Hafiz Muhammad Umar Xinxin Yang Xian Shen Evaluating the weight-adjusted waist index as a predictive tool for sarcopenia and mortality risk Eating and Weight Disorders Sarcopenia WWI Obesity All-cause mortality NHANES Cross-sectional study |
| title | Evaluating the weight-adjusted waist index as a predictive tool for sarcopenia and mortality risk |
| title_full | Evaluating the weight-adjusted waist index as a predictive tool for sarcopenia and mortality risk |
| title_fullStr | Evaluating the weight-adjusted waist index as a predictive tool for sarcopenia and mortality risk |
| title_full_unstemmed | Evaluating the weight-adjusted waist index as a predictive tool for sarcopenia and mortality risk |
| title_short | Evaluating the weight-adjusted waist index as a predictive tool for sarcopenia and mortality risk |
| title_sort | evaluating the weight adjusted waist index as a predictive tool for sarcopenia and mortality risk |
| topic | Sarcopenia WWI Obesity All-cause mortality NHANES Cross-sectional study |
| url | https://doi.org/10.1007/s40519-024-01712-1 |
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