Degenerated (Ancient) Schwannomas: Unraveling Unusual Locations and Treatment Management
Background/Aims:Schwannomas, originating from Schwann cells in peripheral nerve sheaths, exhibit diverse clinical manifestations and unpredictable behavior. Among them, ancient schwannomas, with distinctive degenerative features, present in atypical locations and pose diagnostic challenges. This stu...
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Selcuk University Press
2024-04-01
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| Series: | Genel Tıp Dergisi |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/3366237 |
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| author | Ali Dalgıç Servet Güreşci Bekir Tunç Egemen Işıtan Zeynep Dağlar Emin Çağıl Yigit Can Senol Goksal Gunerhan |
| author_facet | Ali Dalgıç Servet Güreşci Bekir Tunç Egemen Işıtan Zeynep Dağlar Emin Çağıl Yigit Can Senol Goksal Gunerhan |
| author_sort | Ali Dalgıç |
| collection | DOAJ |
| description | Background/Aims:Schwannomas, originating from Schwann cells in peripheral nerve sheaths, exhibit diverse clinical manifestations and unpredictable behavior. Among them, ancient schwannomas, with distinctive degenerative features, present in atypical locations and pose diagnostic challenges. This study explores their unique characteristics and implications for diagnosis and management.
Material and Methods: The study was designed as a retrospective analysis of 7 adult patients aged ≥18 years, diagnosed with paraspinal, presacral, sacral, or para-aortic tumors, all confirmed histologically as ancient schwannomas. Data for analysis were collected from patients treated and followed up at Ankara City Hospital between April 2017 and December 2022. Ethical approval and informed consent were obtained before inclusion in the study.
Results: The most common symptoms included the presence of a local lump (71,4%) and localized or radiating pain (57,1%). Notably, 1 patient (14,2%) was incidentally diagnosed during the evaluation process. Surgical intervention played a crucial role in the management of these tumors, with 71,4% of patients undergoing complete resection, while 28,5% underwent subtotal resection. Tumor recurrence occurred in 42,8% of cases, prompting the administration of radiotherapy as part of the treatment strategy. Imaging findings, particularly on MRI, played a crucial role in the accurate identification of ancient schwannomas. These tumors displayed isointensity on T1-weighted images and heterogeneous hyperintensity on T2-weighted images, along with distinctive heterogeneous contrast enhancement.
Conclusion: Ancient schwannomas exhibit unique histological features and distinctive MRI characteristics, differentiating them from other nerve sheath tumors. Early diagnosis and complete surgical resection offer favorable outcomes. Awareness of this entity is essential for managing peripheral nerve sheath tumors effectively. |
| format | Article |
| id | doaj-art-29d449e210334c9393d34addb106683a |
| institution | Kabale University |
| issn | 2602-3741 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Genel Tıp Dergisi |
| spelling | doaj-art-29d449e210334c9393d34addb106683a2025-01-03T01:05:26ZengSelcuk University PressGenel Tıp Dergisi2602-37412024-04-0134219520010.54005/geneltip.1350844154Degenerated (Ancient) Schwannomas: Unraveling Unusual Locations and Treatment ManagementAli Dalgıç0Servet Güreşci1Bekir Tunç2Egemen Işıtan3Zeynep Dağlar4Emin Çağıl5Yigit Can Senol6Goksal Gunerhan7Medicana International HospitalSAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜT.C. Sağlık Bakanlığı Hitit Üniversitesi Çorum Erol Olçok Eğitim Ve Araştırma HastanesiYüksek İhtisas University, Liv Hospital,SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜSAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜSAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜSAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜBackground/Aims:Schwannomas, originating from Schwann cells in peripheral nerve sheaths, exhibit diverse clinical manifestations and unpredictable behavior. Among them, ancient schwannomas, with distinctive degenerative features, present in atypical locations and pose diagnostic challenges. This study explores their unique characteristics and implications for diagnosis and management. Material and Methods: The study was designed as a retrospective analysis of 7 adult patients aged ≥18 years, diagnosed with paraspinal, presacral, sacral, or para-aortic tumors, all confirmed histologically as ancient schwannomas. Data for analysis were collected from patients treated and followed up at Ankara City Hospital between April 2017 and December 2022. Ethical approval and informed consent were obtained before inclusion in the study. Results: The most common symptoms included the presence of a local lump (71,4%) and localized or radiating pain (57,1%). Notably, 1 patient (14,2%) was incidentally diagnosed during the evaluation process. Surgical intervention played a crucial role in the management of these tumors, with 71,4% of patients undergoing complete resection, while 28,5% underwent subtotal resection. Tumor recurrence occurred in 42,8% of cases, prompting the administration of radiotherapy as part of the treatment strategy. Imaging findings, particularly on MRI, played a crucial role in the accurate identification of ancient schwannomas. These tumors displayed isointensity on T1-weighted images and heterogeneous hyperintensity on T2-weighted images, along with distinctive heterogeneous contrast enhancement. Conclusion: Ancient schwannomas exhibit unique histological features and distinctive MRI characteristics, differentiating them from other nerve sheath tumors. Early diagnosis and complete surgical resection offer favorable outcomes. Awareness of this entity is essential for managing peripheral nerve sheath tumors effectively.https://dergipark.org.tr/tr/download/article-file/3366237schwannomaantikbenign tümörnöral tümörlerschwann hücreleri.schwannomaancientbenign tumorneural tumorsschwann cells. |
| spellingShingle | Ali Dalgıç Servet Güreşci Bekir Tunç Egemen Işıtan Zeynep Dağlar Emin Çağıl Yigit Can Senol Goksal Gunerhan Degenerated (Ancient) Schwannomas: Unraveling Unusual Locations and Treatment Management Genel Tıp Dergisi schwannoma antik benign tümör nöral tümörler schwann hücreleri. schwannoma ancient benign tumor neural tumors schwann cells. |
| title | Degenerated (Ancient) Schwannomas: Unraveling Unusual Locations and Treatment Management |
| title_full | Degenerated (Ancient) Schwannomas: Unraveling Unusual Locations and Treatment Management |
| title_fullStr | Degenerated (Ancient) Schwannomas: Unraveling Unusual Locations and Treatment Management |
| title_full_unstemmed | Degenerated (Ancient) Schwannomas: Unraveling Unusual Locations and Treatment Management |
| title_short | Degenerated (Ancient) Schwannomas: Unraveling Unusual Locations and Treatment Management |
| title_sort | degenerated ancient schwannomas unraveling unusual locations and treatment management |
| topic | schwannoma antik benign tümör nöral tümörler schwann hücreleri. schwannoma ancient benign tumor neural tumors schwann cells. |
| url | https://dergipark.org.tr/tr/download/article-file/3366237 |
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