Remodelling of the immune landscape by IFNγ counteracts IFNγ-dependent tumour escape in mouse tumour models

Remodelling of the immune landscape by IFNγ counteracts IFNγ-dependent tumour escape in mouse tumour models

Abstract Loss of IFNγ-sensitivity by tumours is thought to be a mechanism enabling evasion, but recent studies suggest that IFNγ-resistant tumours can be sensitised for immunotherapy, yet the underlying mechanism remains unclear. Here, we show that IFNγ receptor-deficient B16-F10 mouse melanoma tumo...

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Main Authors: Vivian W. C. Lau, Gracie J. Mead, Zofia Varyova, Julie M. Mazet, Anagha Krishnan, Edward W. Roberts, Gennaro Prota, Uzi Gileadi, Kim S. Midwood, Vincenzo Cerundolo, Audrey Gérard
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54791-0
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