Association Between Helicobacter Pylori Infection and Periodontal and Gastric Diseases: A Meta-Analysis

Association Between Helicobacter Pylori Infection and Periodontal and Gastric Diseases: A Meta-Analysis

Background: Helicobacter pylori (Hp) infection has been implicated in both gastric and extra-gastric diseases, including periodontitis. Methods: This meta-analysis investigated the association between Helicobacter pylori (Hp) infection and periodontitis by systematically reviewing eight studies. The...

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Bibliographic Details
Main Authors: Qinghua Liu, Ying Zhang, Fengxiang Qi
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:International Dental Journal
Subjects:
Helicobacter pylori
Periodontitis
Meta-analysis
Odds ratio
Heterogeneity
Oral health
Online Access:http://www.sciencedirect.com/science/article/pii/S0020653924016459
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Summary:Background: Helicobacter pylori (Hp) infection has been implicated in both gastric and extra-gastric diseases, including periodontitis. Methods: This meta-analysis investigated the association between Helicobacter pylori (Hp) infection and periodontitis by systematically reviewing eight studies. The analysis was conducted using the R package “meta,” employing both fixed effects and random effects models. The level of heterogeneity among the studies was assessed using the I-squared statistic and tau values. Publication bias was evaluated through funnel plots, Begg's rank correlation, and Egger's regression tests to ensure the robustness of the findings. Results: The meta-analysis included a total of 6061 observations, with 1404 cases of periodontitis. The fixed effects model produced an odds ratio (OR) of 2.3392 (95% confidence interval [CI]: 2.0207-2.7078), and the random effects model yielded a similar OR of 2.3220 (95% CI: 2.0050-2.6892). The I-squared statistic indicated low to moderate heterogeneity among the studies. Subgroup analyses demonstrated consistent associations across different Hp diagnostic methods. Conclusion: Hp infection is significantly associated with an increased risk of periodontitis, highlighting its role in both gastric and oral health.
ISSN:0020-6539

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