Comparative Effects of Vitamin D Supplementation on Oxidative Stress in Relapsing–Remitting Multiple Sclerosis
Studies suggest that vitamin D (VitD) may reduce oxidative stress (OS) in multiple sclerosis (MS) patients. This study aimed to compare the effects of various VitD doses on OS in relapsing–remitting MS (RRMS). A 6-month supplementation was introduced using two doses of VitD: 2000 IU/day in the high-...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
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| Series: | Current Issues in Molecular Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1467-3045/46/12/845 |
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| Summary: | Studies suggest that vitamin D (VitD) may reduce oxidative stress (OS) in multiple sclerosis (MS) patients. This study aimed to compare the effects of various VitD doses on OS in relapsing–remitting MS (RRMS). A 6-month supplementation was introduced using two doses of VitD: 2000 IU/day in the high-dose group (HD, <i>n</i> = 23) and 15,960 IU/month in the low-dose group (LD, <i>n</i> = 29). Significant differences in body weight, height, and age were found between groups. A significant increase in the level of VitD (25(OH)D) was noted in both groups (<i>p</i> < 0.01). A significant increase was observed in the levels of LF and MDA (<i>p</i> < 0.01) and a significant decrease in the concentrations of PSH (<i>p</i> < 0.01), CuZnSOD (<i>p</i> = 0.02), and TOS (<i>p</i> < 0.01). A significant positive correlation was observed between serum VitD and SOD (R = 0.38, <i>p</i> < 0.01) and MnSOD (R = 0.31, <i>p</i> < 0.05), as well as a significant negative correlation between serum VitD and MDA (R = −0.31, <i>p</i> = 0.05) at the beginning of the study. At the end of the study, a significant positive correlation was observed between serum VitD and SOD (R = 0.34, <i>p</i> < 0.05) and CuZnSOD (R = 0.51, <i>p</i> < 0.01). In RRMS patients, the VitD doses are probably insufficient to induce a beneficial effect on the pro- and antioxidant balance. |
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| ISSN: | 1467-3037 1467-3045 |