Amino acid-based deep eutectic solvent as a versatile catalyst for the green synthesis of chromenopyrimidines
Abstract A novel deep eutectic solvent (Thr/Mal-DES) was synthesized by mixing one mole of L-threonine (Thr) with one mole of malonic acid (Mal) and was characterized by FT-IR, 1H NMR, TGA/DTA, and densitometry techniques. Then, it was used as a highly effective catalyst for the rapid synthesis of c...
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-08820-7 |
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| author | Afagh Ranjbaran Davood Habibi Arezo Monem Nastaran Dehnokhalaji |
| author_facet | Afagh Ranjbaran Davood Habibi Arezo Monem Nastaran Dehnokhalaji |
| author_sort | Afagh Ranjbaran |
| collection | DOAJ |
| description | Abstract A novel deep eutectic solvent (Thr/Mal-DES) was synthesized by mixing one mole of L-threonine (Thr) with one mole of malonic acid (Mal) and was characterized by FT-IR, 1H NMR, TGA/DTA, and densitometry techniques. Then, it was used as a highly effective catalyst for the rapid synthesis of chromeno[4,3-d]pyrimidines from the reaction of 4-hydroxy-coumarin, urea/thiourea and aldehyde under solvent-free conditions at 80 °C in high yields and short reaction times. |
| format | Article |
| id | doaj-art-298b925baed443b2b51eec72ab768ff8 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-298b925baed443b2b51eec72ab768ff82025-08-20T03:43:11ZengNature PortfolioScientific Reports2045-23222025-07-0115111210.1038/s41598-025-08820-7Amino acid-based deep eutectic solvent as a versatile catalyst for the green synthesis of chromenopyrimidinesAfagh Ranjbaran0Davood Habibi1Arezo Monem2Nastaran Dehnokhalaji3Department of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityDepartment of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityDepartment of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityDepartment of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityAbstract A novel deep eutectic solvent (Thr/Mal-DES) was synthesized by mixing one mole of L-threonine (Thr) with one mole of malonic acid (Mal) and was characterized by FT-IR, 1H NMR, TGA/DTA, and densitometry techniques. Then, it was used as a highly effective catalyst for the rapid synthesis of chromeno[4,3-d]pyrimidines from the reaction of 4-hydroxy-coumarin, urea/thiourea and aldehyde under solvent-free conditions at 80 °C in high yields and short reaction times.https://doi.org/10.1038/s41598-025-08820-7L-threonineMalonic acidDeep eutectic solventCatalysisChromenopyrimidines |
| spellingShingle | Afagh Ranjbaran Davood Habibi Arezo Monem Nastaran Dehnokhalaji Amino acid-based deep eutectic solvent as a versatile catalyst for the green synthesis of chromenopyrimidines Scientific Reports L-threonine Malonic acid Deep eutectic solvent Catalysis Chromenopyrimidines |
| title | Amino acid-based deep eutectic solvent as a versatile catalyst for the green synthesis of chromenopyrimidines |
| title_full | Amino acid-based deep eutectic solvent as a versatile catalyst for the green synthesis of chromenopyrimidines |
| title_fullStr | Amino acid-based deep eutectic solvent as a versatile catalyst for the green synthesis of chromenopyrimidines |
| title_full_unstemmed | Amino acid-based deep eutectic solvent as a versatile catalyst for the green synthesis of chromenopyrimidines |
| title_short | Amino acid-based deep eutectic solvent as a versatile catalyst for the green synthesis of chromenopyrimidines |
| title_sort | amino acid based deep eutectic solvent as a versatile catalyst for the green synthesis of chromenopyrimidines |
| topic | L-threonine Malonic acid Deep eutectic solvent Catalysis Chromenopyrimidines |
| url | https://doi.org/10.1038/s41598-025-08820-7 |
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