番荔枝内酯单体Desacetyluvaricin对肝癌细胞株生长和凋亡的影响
[目的]探讨Desacetyluvaricin在体外对肝癌HpG2.2.15细胞株生长和凋亡的作用及机制。[方法]处于生长期的人肝癌HepG2.2.15细胞分为3组：对照组,Desacetyluvaricin组和顺铂组。用MTT法检测各组肿瘤细胞增殖情况,流式细胞仪检测各组细胞周期、细胞调亡以及凋亡基因Fas的表达情况,比较Desacetyluvaricin与顺铂的疗效。[结果]Desacetyluvaricin对肝癌细胞增殖的抑制率高达62.2%。Desacetyluvaricin抑制肝癌细胞增殖的机制可能为阻滞肝癌HepG2.2.15细胞从G1期进入S期,从而抑制了肿瘤细胞的增殖,同时通过...
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Editorial Office of Journal of Sun Yat-sen University
2007-01-01
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| Series: | Zhongshan Daxue xuebao. Yixue kexue ban |
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| Online Access: | http://xuebaoyx.sysu.edu.cn/zh/article/43580690/ |
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| author | 陈孝银 周光雄 赵昌林 夏芳 毛慧君 江振友 敖杰男 |
| author_facet | 陈孝银 周光雄 赵昌林 夏芳 毛慧君 江振友 敖杰男 |
| author_sort | 陈孝银 |
| collection | DOAJ |
| description | [目的]探讨Desacetyluvaricin在体外对肝癌HpG2.2.15细胞株生长和凋亡的作用及机制。[方法]处于生长期的人肝癌HepG2.2.15细胞分为3组：对照组,Desacetyluvaricin组和顺铂组。用MTT法检测各组肿瘤细胞增殖情况,流式细胞仪检测各组细胞周期、细胞调亡以及凋亡基因Fas的表达情况,比较Desacetyluvaricin与顺铂的疗效。[结果]Desacetyluvaricin对肝癌细胞增殖的抑制率高达62.2%。Desacetyluvaricin抑制肝癌细胞增殖的机制可能为阻滞肝癌HepG2.2.15细胞从G1期进入S期,从而抑制了肿瘤细胞的增殖,同时通过促进Fas表达,诱导HepG2.2.15细胞凋亡。其诱导Fas表达的效果还优于顺铂。[结论]Desacetyluvaricin可能通过延缓细胞G1期及诱导细胞凋亡等机制,对肝癌细胞的增殖有一定的抑制作用。 |
| format | Article |
| id | doaj-art-29887e44977d40e6946ba8f7f3b53ae4 |
| institution | Kabale University |
| issn | 1672-3554 |
| language | zho |
| publishDate | 2007-01-01 |
| publisher | Editorial Office of Journal of Sun Yat-sen University |
| record_format | Article |
| series | Zhongshan Daxue xuebao. Yixue kexue ban |
| spelling | doaj-art-29887e44977d40e6946ba8f7f3b53ae42025-01-15T03:15:45ZzhoEditorial Office of Journal of Sun Yat-sen UniversityZhongshan Daxue xuebao. Yixue kexue ban1672-35542007-01-012843580690番荔枝内酯单体Desacetyluvaricin对肝癌细胞株生长和凋亡的影响陈孝银周光雄赵昌林夏芳毛慧君江振友敖杰男[目的]探讨Desacetyluvaricin在体外对肝癌HpG2.2.15细胞株生长和凋亡的作用及机制。[方法]处于生长期的人肝癌HepG2.2.15细胞分为3组：对照组,Desacetyluvaricin组和顺铂组。用MTT法检测各组肿瘤细胞增殖情况,流式细胞仪检测各组细胞周期、细胞调亡以及凋亡基因Fas的表达情况,比较Desacetyluvaricin与顺铂的疗效。[结果]Desacetyluvaricin对肝癌细胞增殖的抑制率高达62.2%。Desacetyluvaricin抑制肝癌细胞增殖的机制可能为阻滞肝癌HepG2.2.15细胞从G1期进入S期,从而抑制了肿瘤细胞的增殖,同时通过促进Fas表达,诱导HepG2.2.15细胞凋亡。其诱导Fas表达的效果还优于顺铂。[结论]Desacetyluvaricin可能通过延缓细胞G1期及诱导细胞凋亡等机制,对肝癌细胞的增殖有一定的抑制作用。http://xuebaoyx.sysu.edu.cn/zh/article/43580690/Desacetyluvaricin肝癌细胞周期细胞凋亡Fas基因 |
| spellingShingle | 陈孝银 周光雄 赵昌林 夏芳 毛慧君 江振友 敖杰男 番荔枝内酯单体Desacetyluvaricin对肝癌细胞株生长和凋亡的影响 Zhongshan Daxue xuebao. Yixue kexue ban Desacetyluvaricin 肝癌 细胞周期 细胞凋亡 Fas基因 |
| title | 番荔枝内酯单体Desacetyluvaricin对肝癌细胞株生长和凋亡的影响 |
| title_full | 番荔枝内酯单体Desacetyluvaricin对肝癌细胞株生长和凋亡的影响 |
| title_fullStr | 番荔枝内酯单体Desacetyluvaricin对肝癌细胞株生长和凋亡的影响 |
| title_full_unstemmed | 番荔枝内酯单体Desacetyluvaricin对肝癌细胞株生长和凋亡的影响 |
| title_short | 番荔枝内酯单体Desacetyluvaricin对肝癌细胞株生长和凋亡的影响 |
| title_sort | 番荔枝内酯单体desacetyluvaricin对肝癌细胞株生长和凋亡的影响 |
| topic | Desacetyluvaricin 肝癌 细胞周期 细胞凋亡 Fas基因 |
| url | http://xuebaoyx.sysu.edu.cn/zh/article/43580690/ |
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