Effect of quercetin on the transport of ritonavir to the central nervous system in vitro and in vivo

Effect of quercetin on the transport of ritonavir to the central nervous system in vitro and in vivo

The aim of this study was to identify an effective flavonoid that could improve the intracellular accumulation of ritonavir in human brain-microvascular endothelial cells (HBMECs). An in vivo experiment on Sprague-Dawley rats was then designed to further determine the flavonoid’s impact on the pharm...

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Bibliographic Details
Main Authors: Liang Gongwen, Li Na, Ma Liping, Qian Zhonglian, Sun Yuwen, Shi Luwen, Zhao Libo
Format: Article
Language:English
Published: Sciendo 2016-03-01
Series:Acta Pharmaceutica
Subjects:
quercetin
flavonoids
ritonavir
blood-brain barrier
pharmacokinetics
Online Access:https://doi.org/10.1515/acph-2016-0009
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