Association between serum vitamin B6 concentration and risk of osteoporosis in the middle-aged and older people in China: a cross-sectional study
Objective To determine the relationship between serum vitamin B6 (Vit B6) concentration and the status of bone mineral density and identify the relationship between serum Vit B6 and bone metabolism parameters in middle-aged and older people in China.Design The present study was a cross-sectional stu...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2019-07-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/7/e028129.full |
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| author | Yong-Jun Wang Yan Zhang Hao Zhang Lin Chen Chen-guang Li Qiang Wang Xiaofeng Qi Liang Qiao Wei-wei Da Xue-jun Cui Sheng Lu Bing Shu |
| author_facet | Yong-Jun Wang Yan Zhang Hao Zhang Lin Chen Chen-guang Li Qiang Wang Xiaofeng Qi Liang Qiao Wei-wei Da Xue-jun Cui Sheng Lu Bing Shu |
| author_sort | Yong-Jun Wang |
| collection | DOAJ |
| description | Objective To determine the relationship between serum vitamin B6 (Vit B6) concentration and the status of bone mineral density and identify the relationship between serum Vit B6 and bone metabolism parameters in middle-aged and older people in China.Design The present study was a cross-sectional study within the framework of an ongoing prospective population-based cohort study.Setting and participants A total of 1829 residents (men ≥50 years and women ≥45 years) from two subdistricts were recruited from July 2015 to February 2016 in Shanghai, China.Measures Recruited residents were grouped (control, osteopenia and osteoporosis) according to their lumbar spine bone mineral density, measured through dual-energy X-ray absorptiometry. Serum Vit B6 concentrations, bone turnover marker concentrations and calcium and phosphorus metabolism parameters were assessed.Results No significant linear trend between serum Vit B6 concentrations and lumbar bone mass was observed in the men. In the women, the average osteoporosis risk was 61% higher at serum Vit B6 concentrations of <19.2 μg/L than at those of >26.9 μg/L (OR 1.61, 95% CI 1.00 to 2.58). However, there was no significance after controlling of serum 25-hydroxy-vitamin D concentration and parathyroid hormone concentration, respectively. In the osteoporotic women, the serum Vit B6 concentration was significantly negatively correlated to concentrations of bone turnover marker including N-terminal propeptide of type I collagen, β-C-terminal telopeptide of type I collagen and osteocalcin. It was also positively related to the serum 25-hydroxy-vitamin D concentration and inversely related to the serum parathyroid hormone concentration.Conclusions A relatively low serum Vit B6 concentration, even in the normal range, may be a risk factor for osteoporosis in postmenopausal women, which is dependent on serum 25-hydroxy-vitamin D concentration and parathyroid hormone concentration.Trial registration number NCT02958020; Post-results. |
| format | Article |
| id | doaj-art-296f9d4425bc4938b874cc781cd657cf |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-296f9d4425bc4938b874cc781cd657cf2024-11-23T14:15:12ZengBMJ Publishing GroupBMJ Open2044-60552019-07-019710.1136/bmjopen-2018-028129Association between serum vitamin B6 concentration and risk of osteoporosis in the middle-aged and older people in China: a cross-sectional studyYong-Jun Wang0Yan Zhang1Hao Zhang2Lin Chen3Chen-guang Li4Qiang Wang5Xiaofeng Qi6Liang Qiao7Wei-wei Da8Xue-jun Cui9Sheng Lu10Bing Shu112 China National Clinical Research centre for Neurological Diseases, Beijing, ChinaBeijing Neurosurgical Institute, Beijing, China1 Department of Cell Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Medical Epigenetics, Tianjin Institute of Immunology, Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China1 Beijing Huilongguan Hospital, Beijing, ChinaLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Hepatobiliary Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People’s Republic of China1 Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Orthopedic, Longhua Hospital, Shanghai University of Traditional Chinese Medicinev, Shanghai, China1 Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaObjective To determine the relationship between serum vitamin B6 (Vit B6) concentration and the status of bone mineral density and identify the relationship between serum Vit B6 and bone metabolism parameters in middle-aged and older people in China.Design The present study was a cross-sectional study within the framework of an ongoing prospective population-based cohort study.Setting and participants A total of 1829 residents (men ≥50 years and women ≥45 years) from two subdistricts were recruited from July 2015 to February 2016 in Shanghai, China.Measures Recruited residents were grouped (control, osteopenia and osteoporosis) according to their lumbar spine bone mineral density, measured through dual-energy X-ray absorptiometry. Serum Vit B6 concentrations, bone turnover marker concentrations and calcium and phosphorus metabolism parameters were assessed.Results No significant linear trend between serum Vit B6 concentrations and lumbar bone mass was observed in the men. In the women, the average osteoporosis risk was 61% higher at serum Vit B6 concentrations of <19.2 μg/L than at those of >26.9 μg/L (OR 1.61, 95% CI 1.00 to 2.58). However, there was no significance after controlling of serum 25-hydroxy-vitamin D concentration and parathyroid hormone concentration, respectively. In the osteoporotic women, the serum Vit B6 concentration was significantly negatively correlated to concentrations of bone turnover marker including N-terminal propeptide of type I collagen, β-C-terminal telopeptide of type I collagen and osteocalcin. It was also positively related to the serum 25-hydroxy-vitamin D concentration and inversely related to the serum parathyroid hormone concentration.Conclusions A relatively low serum Vit B6 concentration, even in the normal range, may be a risk factor for osteoporosis in postmenopausal women, which is dependent on serum 25-hydroxy-vitamin D concentration and parathyroid hormone concentration.Trial registration number NCT02958020; Post-results.https://bmjopen.bmj.com/content/9/7/e028129.full |
| spellingShingle | Yong-Jun Wang Yan Zhang Hao Zhang Lin Chen Chen-guang Li Qiang Wang Xiaofeng Qi Liang Qiao Wei-wei Da Xue-jun Cui Sheng Lu Bing Shu Association between serum vitamin B6 concentration and risk of osteoporosis in the middle-aged and older people in China: a cross-sectional study BMJ Open |
| title | Association between serum vitamin B6 concentration and risk of osteoporosis in the middle-aged and older people in China: a cross-sectional study |
| title_full | Association between serum vitamin B6 concentration and risk of osteoporosis in the middle-aged and older people in China: a cross-sectional study |
| title_fullStr | Association between serum vitamin B6 concentration and risk of osteoporosis in the middle-aged and older people in China: a cross-sectional study |
| title_full_unstemmed | Association between serum vitamin B6 concentration and risk of osteoporosis in the middle-aged and older people in China: a cross-sectional study |
| title_short | Association between serum vitamin B6 concentration and risk of osteoporosis in the middle-aged and older people in China: a cross-sectional study |
| title_sort | association between serum vitamin b6 concentration and risk of osteoporosis in the middle aged and older people in china a cross sectional study |
| url | https://bmjopen.bmj.com/content/9/7/e028129.full |
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