Physical Performance and Activity in Older Prostate Cancer Survivors in Comparison with Population-based Matched Controls
Background and objective: Whether radical prostate cancer treatment affects long-term physical performance and physical activity in older men is not known. We aimed to compare physical performance and self-reported physical activity between relapse-free older prostate cancer survivors and population...
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Elsevier
2025-01-01
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| Series: | European Urology Open Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666168324014277 |
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| author | Reidun Sletten Marit Slaaen Line Merethe Oldervoll Håvard Kjesbu Skjellegrind Jūratė Šaltytė Benth Lennart Åstrøm Øyvind Kirkevold Sverre Bergh Bjørn Henning Grønberg Siri Rostoft Asta Bye Paul Jarle Mork Ola Berger Christiansen |
| author_facet | Reidun Sletten Marit Slaaen Line Merethe Oldervoll Håvard Kjesbu Skjellegrind Jūratė Šaltytė Benth Lennart Åstrøm Øyvind Kirkevold Sverre Bergh Bjørn Henning Grønberg Siri Rostoft Asta Bye Paul Jarle Mork Ola Berger Christiansen |
| author_sort | Reidun Sletten |
| collection | DOAJ |
| description | Background and objective: Whether radical prostate cancer treatment affects long-term physical performance and physical activity in older men is not known. We aimed to compare physical performance and self-reported physical activity between relapse-free older prostate cancer survivors and population-based controls. Methods: A single-centre, cross-sectional study including 109 men aged ≥70 yr receiving robotic-assisted radical prostatectomy (61.5%) or external beam radiotherapy (38.5%) between 2014 and 2018 was conducted. Population-based matched (age, gender, and education) controls (n = 327) were drawn from the Trøndelag Health Study. The primary (the Short Physical Performance Battery [SPPB] summary score) and secondary (gait speed, grip strength, one-legged balance, and the self-reported Physical Activity Index) outcomes were compared between survivors and controls by adjusted linear mixed models. Key findings and limitations: The SPPB score, gait speed, and Physical Activity Index did not differ between survivors (mean age 78.3 yr, mean time since treatment 52.9 mo) and controls (mean age 78.2 yr). Survivors had slightly poorer grip strength (regression coefficient [RC] –5.81, p < 0.001, 95% confidence interval [CI] –7.46; –4.17) and one-legged balance (RC –4.36, p < 0.001, 95% CI –6.72; –2.00; adjusted models), but the clinical significance is uncertain. Small sample size and potential selection of the fittest survivors are limitations that may reduce the generalisability of our findings. Conclusions and clinical implications: 3 to 8 yr after radical prostate cancer treatment, older men’s overall physical performance and physical activity level were comparable with those of matched controls. This suggests that the treatment had little impact on functional status. Patient summary: In this study, we investigated physical function in older men several years after they had undergone curatively intended treatment for prostate cancer in comparison with men in a general population of the same age and education. We found that physical function was similar, except slightly poorer grip strength and balance on one leg in men treated for prostate cancer. We conclude that the overall physical function was comparable with that of the general population and believe that this indicates that prostate cancer treatment was well tolerated despite older age. |
| format | Article |
| id | doaj-art-2962f7e0e7d744ffb3564abcec2359d5 |
| institution | Kabale University |
| issn | 2666-1683 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | European Urology Open Science |
| spelling | doaj-art-2962f7e0e7d744ffb3564abcec2359d52025-01-17T04:52:21ZengElsevierEuropean Urology Open Science2666-16832025-01-01718795Physical Performance and Activity in Older Prostate Cancer Survivors in Comparison with Population-based Matched ControlsReidun Sletten0Marit Slaaen1Line Merethe Oldervoll2Håvard Kjesbu Skjellegrind3Jūratė Šaltytė Benth4Lennart Åstrøm5Øyvind Kirkevold6Sverre Bergh7Bjørn Henning Grønberg8Siri Rostoft9Asta Bye10Paul Jarle Mork11Ola Berger Christiansen12Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; The Research Center for Age-Related Functional Decline and Disease, Innlandet Hospital Trust, Ottestad, Norway; Department of Oncology and Palliative Care, Innlandet Hospital Trust, Gjøvik/Lillehammer, Norway; Corresponding author. The Research Center for Age-Related Functional Decline and Disease (AFS), Innlandet Hospital Trust, PB 68, 2313 Ottestad, Norway. Tel. +47 976 58 025.The Research Center for Age-Related Functional Decline and Disease, Innlandet Hospital Trust, Ottestad, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, NorwayCentre for Crisis Psychology, Faculty of Psychology, University of Bergen, Bergen, Norway; The National Institute on Intellectual Disability and Community, Department of Mental Health, Faculty of Medicine and Health Sciences, NTNU, Trondheim, NorwayHUNT Research Centre, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Levanger, Norway; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, NorwayThe Research Center for Age-Related Functional Decline and Disease, Innlandet Hospital Trust, Ottestad, Norway; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway; Health Services Research Unit, Akershus University Hospital, Lørenskog, NorwaySection of Clinical and Experimental Oncology, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, SwedenThe Research Center for Age-Related Functional Decline and Disease, Innlandet Hospital Trust, Ottestad, Norway; Faculty of Health, Care and Nursing, NTNU Gjøvik, Gjøvik, Norway; The Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, NorwayThe Research Center for Age-Related Functional Decline and Disease, Innlandet Hospital Trust, Ottestad, Norway; The Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, NorwayDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, Trondheim, Norway; Department of Oncology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, NorwayInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Geriatric Medicine, Oslo University Hospital, Oslo, NorwayDepartment of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, NorwayDepartment of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, NorwayThe Research Center for Age-Related Functional Decline and Disease, Innlandet Hospital Trust, Ottestad, Norway; Department of Urology, Innlandet Hospital Trust, Hamar, NorwayBackground and objective: Whether radical prostate cancer treatment affects long-term physical performance and physical activity in older men is not known. We aimed to compare physical performance and self-reported physical activity between relapse-free older prostate cancer survivors and population-based controls. Methods: A single-centre, cross-sectional study including 109 men aged ≥70 yr receiving robotic-assisted radical prostatectomy (61.5%) or external beam radiotherapy (38.5%) between 2014 and 2018 was conducted. Population-based matched (age, gender, and education) controls (n = 327) were drawn from the Trøndelag Health Study. The primary (the Short Physical Performance Battery [SPPB] summary score) and secondary (gait speed, grip strength, one-legged balance, and the self-reported Physical Activity Index) outcomes were compared between survivors and controls by adjusted linear mixed models. Key findings and limitations: The SPPB score, gait speed, and Physical Activity Index did not differ between survivors (mean age 78.3 yr, mean time since treatment 52.9 mo) and controls (mean age 78.2 yr). Survivors had slightly poorer grip strength (regression coefficient [RC] –5.81, p < 0.001, 95% confidence interval [CI] –7.46; –4.17) and one-legged balance (RC –4.36, p < 0.001, 95% CI –6.72; –2.00; adjusted models), but the clinical significance is uncertain. Small sample size and potential selection of the fittest survivors are limitations that may reduce the generalisability of our findings. Conclusions and clinical implications: 3 to 8 yr after radical prostate cancer treatment, older men’s overall physical performance and physical activity level were comparable with those of matched controls. This suggests that the treatment had little impact on functional status. Patient summary: In this study, we investigated physical function in older men several years after they had undergone curatively intended treatment for prostate cancer in comparison with men in a general population of the same age and education. We found that physical function was similar, except slightly poorer grip strength and balance on one leg in men treated for prostate cancer. We conclude that the overall physical function was comparable with that of the general population and believe that this indicates that prostate cancer treatment was well tolerated despite older age.http://www.sciencedirect.com/science/article/pii/S2666168324014277Cancer survivorsGrip strengthOlderOne-legged balanceProstate cancerPhysical activity |
| spellingShingle | Reidun Sletten Marit Slaaen Line Merethe Oldervoll Håvard Kjesbu Skjellegrind Jūratė Šaltytė Benth Lennart Åstrøm Øyvind Kirkevold Sverre Bergh Bjørn Henning Grønberg Siri Rostoft Asta Bye Paul Jarle Mork Ola Berger Christiansen Physical Performance and Activity in Older Prostate Cancer Survivors in Comparison with Population-based Matched Controls European Urology Open Science Cancer survivors Grip strength Older One-legged balance Prostate cancer Physical activity |
| title | Physical Performance and Activity in Older Prostate Cancer Survivors in Comparison with Population-based Matched Controls |
| title_full | Physical Performance and Activity in Older Prostate Cancer Survivors in Comparison with Population-based Matched Controls |
| title_fullStr | Physical Performance and Activity in Older Prostate Cancer Survivors in Comparison with Population-based Matched Controls |
| title_full_unstemmed | Physical Performance and Activity in Older Prostate Cancer Survivors in Comparison with Population-based Matched Controls |
| title_short | Physical Performance and Activity in Older Prostate Cancer Survivors in Comparison with Population-based Matched Controls |
| title_sort | physical performance and activity in older prostate cancer survivors in comparison with population based matched controls |
| topic | Cancer survivors Grip strength Older One-legged balance Prostate cancer Physical activity |
| url | http://www.sciencedirect.com/science/article/pii/S2666168324014277 |
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