Loop33 × 123 CAR-T targeting CD33 and CD123 against immune escape in acute myeloid leukemia

Loop33 × 123 CAR-T targeting CD33 and CD123 against immune escape in acute myeloid leukemia

Abstract Background Immunotherapy, such as chimeric antigen receptor T (CAR-T) cells targeting CD33 or CD123, has been well developed over the past decade for the treatment of acute myeloid leukemia (AML). However, the inability to sustain tumor-free survival and the possibility of relapse due to an...

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Bibliographic Details
Main Authors: Haotian Ma, Zhifeng Yan, Runxia Gu, Yingxi Xu, Shaowei Qiu, Haiyan Xing, Kejing Tang, Zheng Tian, Qing Rao, Min Wang, Jianxiang Wang
Format: Article
Language:English
Published: Springer 2024-11-01
Series:Cancer Immunology, Immunotherapy
Subjects:
AML
Chimeric antigen receptor
CD33
CD123
Online Access:https://doi.org/10.1007/s00262-024-03847-7
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