Comparison of steroid and platelet-rich plasma (prp) applications in the treatment of collagenase induced tendinopathy in rabbit
<b>Aim: </b>The aim of this study was to evaluate histopathologically the therapeutic effects of platelet-rich plasma (PRP) and MPA (methylprednisolone acetate) injections in rabbits achill tendinopathies induced by collagenase (Collagenase Type I)<p> <b>Materials and Methods...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
2021-06-01
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1351 |
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| author | Nuriza Zamirbekova Nuri Yavru |
| author_facet | Nuriza Zamirbekova Nuri Yavru |
| author_sort | Nuriza Zamirbekova |
| collection | DOAJ |
| description | <b>Aim: </b>The aim of this study was to evaluate histopathologically the therapeutic
effects of platelet-rich plasma (PRP) and MPA (methylprednisolone acetate)
injections in rabbits achill tendinopathies induced by collagenase (Collagenase
Type I)<p>
<b>Materials and Methods: </b>Achilles tendinopathy was formed with intrathendinous
injections of type I collagenase into the proximal and distal regions of
the right and left achilles tendons of 23 rabbits. PRP was injected distal to the
right Achilles tendons and MPA to the distal of the left Achilles tendons. A 0,9%
saline solution was also injected into the proximal parts of all achilles tendons.
Rabbits were euthanized 3, 6, and 8 weeks after the therapeutic injections. The
degree of histopathological degeneration of the tendons was made according
to the Modified Movin scoring.<p>
<b>Results:</b> Statistically significant differences were detected between the treatment
groups and the 0.9% saline injected group (p<0.05). In the histopathological
evaluations performed at the end of the 6th week no statistically
significant difference was detected between the treatment groups (p>0.05)
without tenocyte nuclei (p<0.05). At the end of the 8 weeks vascularization
and tenocyte nuclei (p<0.05) parameters was observed better in the Achilles
tendons of the rabbits undergoing PRP injection compared to rabbits with
MPA application.<p>
<b>Conclusion:</b> In conclusion, we consider that PRP injections tend to provide
an earlier improvement in the treatment of tendinopathy compared to MPA
injection. |
| format | Article |
| id | doaj-art-2900a685ead04195a8cbe0047878fef0 |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publishDate | 2021-06-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-2900a685ead04195a8cbe0047878fef02025-01-03T01:36:18ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19532021-06-0137282921351Comparison of steroid and platelet-rich plasma (prp) applications in the treatment of collagenase induced tendinopathy in rabbitNuriza ZamirbekovaNuri Yavru<b>Aim: </b>The aim of this study was to evaluate histopathologically the therapeutic effects of platelet-rich plasma (PRP) and MPA (methylprednisolone acetate) injections in rabbits achill tendinopathies induced by collagenase (Collagenase Type I)<p> <b>Materials and Methods: </b>Achilles tendinopathy was formed with intrathendinous injections of type I collagenase into the proximal and distal regions of the right and left achilles tendons of 23 rabbits. PRP was injected distal to the right Achilles tendons and MPA to the distal of the left Achilles tendons. A 0,9% saline solution was also injected into the proximal parts of all achilles tendons. Rabbits were euthanized 3, 6, and 8 weeks after the therapeutic injections. The degree of histopathological degeneration of the tendons was made according to the Modified Movin scoring.<p> <b>Results:</b> Statistically significant differences were detected between the treatment groups and the 0.9% saline injected group (p<0.05). In the histopathological evaluations performed at the end of the 6th week no statistically significant difference was detected between the treatment groups (p>0.05) without tenocyte nuclei (p<0.05). At the end of the 8 weeks vascularization and tenocyte nuclei (p<0.05) parameters was observed better in the Achilles tendons of the rabbits undergoing PRP injection compared to rabbits with MPA application.<p> <b>Conclusion:</b> In conclusion, we consider that PRP injections tend to provide an earlier improvement in the treatment of tendinopathy compared to MPA injection.http://eurasianjvetsci.org/pdf.php3?id=1351achilles tendinopathycollagenase type imethylprednisoloneprpsteroid |
| spellingShingle | Nuriza Zamirbekova Nuri Yavru Comparison of steroid and platelet-rich plasma (prp) applications in the treatment of collagenase induced tendinopathy in rabbit Eurasian Journal of Veterinary Sciences achilles tendinopathy collagenase type i methylprednisolone prp steroid |
| title | Comparison of steroid and platelet-rich plasma (prp) applications in the treatment of collagenase induced tendinopathy in rabbit |
| title_full | Comparison of steroid and platelet-rich plasma (prp) applications in the treatment of collagenase induced tendinopathy in rabbit |
| title_fullStr | Comparison of steroid and platelet-rich plasma (prp) applications in the treatment of collagenase induced tendinopathy in rabbit |
| title_full_unstemmed | Comparison of steroid and platelet-rich plasma (prp) applications in the treatment of collagenase induced tendinopathy in rabbit |
| title_short | Comparison of steroid and platelet-rich plasma (prp) applications in the treatment of collagenase induced tendinopathy in rabbit |
| title_sort | comparison of steroid and platelet rich plasma prp applications in the treatment of collagenase induced tendinopathy in rabbit |
| topic | achilles tendinopathy collagenase type i methylprednisolone prp steroid |
| url | http://eurasianjvetsci.org/pdf.php3?id=1351 |
| work_keys_str_mv | AT nurizazamirbekova comparisonofsteroidandplateletrichplasmaprpapplicationsinthetreatmentofcollagenaseinducedtendinopathyinrabbit AT nuriyavru comparisonofsteroidandplateletrichplasmaprpapplicationsinthetreatmentofcollagenaseinducedtendinopathyinrabbit |