Supplementary oxygen efficacy for chronic pulmonary disorders and exertion desaturation
Introduction Exertion-induced desaturation (EID) is a common complication of numerous pulmonary disorders and often treated with supplementary oxygen during exertion. We performed a systematic review and meta-analysis of randomised clinical trials (RCTs) to evaluate the efficacy of supplementary oxy...
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2024-12-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/10/6/00411-2024.full |
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| author | Paraschos Archontakis Barakakis Adam Wolfe Andrei Schwartz Gabriel J. Hernandez Romero Vipul Gidwani Shaylika Chauhan Shinichi Arizono Ralph J. Panos Spyridon Fortis |
| author_facet | Paraschos Archontakis Barakakis Adam Wolfe Andrei Schwartz Gabriel J. Hernandez Romero Vipul Gidwani Shaylika Chauhan Shinichi Arizono Ralph J. Panos Spyridon Fortis |
| author_sort | Paraschos Archontakis Barakakis |
| collection | DOAJ |
| description | Introduction
Exertion-induced desaturation (EID) is a common complication of numerous pulmonary disorders and often treated with supplementary oxygen during exertion. We performed a systematic review and meta-analysis of randomised clinical trials (RCTs) to evaluate the efficacy of supplementary oxygen for EID in pulmonary disorders.
Material and methods
Medline and Embase were systematically searched from July 2022 to June 2023 following PRISMA guidelines. RCTs that met predefined inclusion criteria were included. Means and standard deviations were extracted and standardised mean differences (SMDs), the difference in means between groups divided by the standard deviation, and 95% confidence intervals were calculated. Exercise capacity was the primary outcome; exercise dyspnoea, baseline dyspnoea and quality of life were secondary objectives. The immediate, post-rehabilitation, short-term and ambulatory effects of oxygen supplementation were evaluated.
Results
We included 15 studies in our analysis. Oxygen supplementation to treat adult EID had been investigated for COPD and idiopathic pulmonary fibrosis (IPF) only. Oxygen supplementation was superior to placebo for its immediate effect on exercise capacity for COPD (SMD 0.42, 95% CI 0.15–0.69, I2=3%) and IPF (SMD 0.41, 95% CI 0.08–0.75, I2=57%) and exercise dyspnoea for COPD (SMD −0.40, 95% CI −0.76–−0.04, I2=31%). Sensitivity analysis revealed similar results.
Conclusions
Our study revealed the efficacy of supplemental oxygen for EID and only a positive immediate effect on exercise capacity and dyspnoea, but no improvement in other short-term or long-term measures. |
| format | Article |
| id | doaj-art-28ff5bdb69564709b1977da164d626d0 |
| institution | Kabale University |
| issn | 2312-0541 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj-art-28ff5bdb69564709b1977da164d626d02025-01-14T09:50:22ZengEuropean Respiratory SocietyERJ Open Research2312-05412024-12-0110610.1183/23120541.00411-202400411-2024Supplementary oxygen efficacy for chronic pulmonary disorders and exertion desaturationParaschos Archontakis Barakakis0Adam Wolfe1Andrei Schwartz2Gabriel J. Hernandez Romero3Vipul Gidwani4Shaylika Chauhan5Shinichi Arizono6Ralph J. Panos7Spyridon Fortis8 Redington-Fairview General Hospital, Skowhegan, ME, USA Division of Pulmonary, Critical Care, and Occupational Medicine, Department of Internal Medicine, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, USA Division of Pulmonary, Critical Care, and Occupational Medicine, Department of Internal Medicine, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, USA Department of Medicine, Albert Einstein College of Medicine/Jacobi Medical Center, Bronx, NY, USA Medicine Institute, Geisinger Medical Center, Danville, PA, USA Medicine Institute, Geisinger Medical Center, Danville, PA, USA School of Rehabilitation Sciences, Seirei Christopher University, Hamamatsu, Japan Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA Division of Pulmonary, Critical Care, and Occupational Medicine, Department of Internal Medicine, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, USA Introduction Exertion-induced desaturation (EID) is a common complication of numerous pulmonary disorders and often treated with supplementary oxygen during exertion. We performed a systematic review and meta-analysis of randomised clinical trials (RCTs) to evaluate the efficacy of supplementary oxygen for EID in pulmonary disorders. Material and methods Medline and Embase were systematically searched from July 2022 to June 2023 following PRISMA guidelines. RCTs that met predefined inclusion criteria were included. Means and standard deviations were extracted and standardised mean differences (SMDs), the difference in means between groups divided by the standard deviation, and 95% confidence intervals were calculated. Exercise capacity was the primary outcome; exercise dyspnoea, baseline dyspnoea and quality of life were secondary objectives. The immediate, post-rehabilitation, short-term and ambulatory effects of oxygen supplementation were evaluated. Results We included 15 studies in our analysis. Oxygen supplementation to treat adult EID had been investigated for COPD and idiopathic pulmonary fibrosis (IPF) only. Oxygen supplementation was superior to placebo for its immediate effect on exercise capacity for COPD (SMD 0.42, 95% CI 0.15–0.69, I2=3%) and IPF (SMD 0.41, 95% CI 0.08–0.75, I2=57%) and exercise dyspnoea for COPD (SMD −0.40, 95% CI −0.76–−0.04, I2=31%). Sensitivity analysis revealed similar results. Conclusions Our study revealed the efficacy of supplemental oxygen for EID and only a positive immediate effect on exercise capacity and dyspnoea, but no improvement in other short-term or long-term measures.http://openres.ersjournals.com/content/10/6/00411-2024.full |
| spellingShingle | Paraschos Archontakis Barakakis Adam Wolfe Andrei Schwartz Gabriel J. Hernandez Romero Vipul Gidwani Shaylika Chauhan Shinichi Arizono Ralph J. Panos Spyridon Fortis Supplementary oxygen efficacy for chronic pulmonary disorders and exertion desaturation ERJ Open Research |
| title | Supplementary oxygen efficacy for chronic pulmonary disorders and exertion desaturation |
| title_full | Supplementary oxygen efficacy for chronic pulmonary disorders and exertion desaturation |
| title_fullStr | Supplementary oxygen efficacy for chronic pulmonary disorders and exertion desaturation |
| title_full_unstemmed | Supplementary oxygen efficacy for chronic pulmonary disorders and exertion desaturation |
| title_short | Supplementary oxygen efficacy for chronic pulmonary disorders and exertion desaturation |
| title_sort | supplementary oxygen efficacy for chronic pulmonary disorders and exertion desaturation |
| url | http://openres.ersjournals.com/content/10/6/00411-2024.full |
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