Advances in fear memory erasure and its neural mechanisms
BackgroundIn nature, animals must learn to recognize danger signals and respond immediately to threats to improve their environmental adaptation. However, excessive fear responses can lead to diseases such as post-traumatic stress disorder, wherein traumatic events result in persistent traumatic mem...
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| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1481450/full |
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| author | Wenbo Guo Xibo Wang Xibo Wang Zihan Zhou Zihan Zhou Yuhui Li Yuhui Li Yani Hou Keyan Wang Ruyuan Wei Xiaoyu Ma Hao Zhang |
| author_facet | Wenbo Guo Xibo Wang Xibo Wang Zihan Zhou Zihan Zhou Yuhui Li Yuhui Li Yani Hou Keyan Wang Ruyuan Wei Xiaoyu Ma Hao Zhang |
| author_sort | Wenbo Guo |
| collection | DOAJ |
| description | BackgroundIn nature, animals must learn to recognize danger signals and respond immediately to threats to improve their environmental adaptation. However, excessive fear responses can lead to diseases such as post-traumatic stress disorder, wherein traumatic events result in persistent traumatic memories. Therefore, erasing pathological fear memories in vivo is a crucial topic in neuroscience for understanding the nature of memories and treating clinically relevant diseases.Main textThis article reviews recent studies on fear memory erasure, erasure of short- and long-term memory, fear memory erasure and neuroplasticity, the neural circuitry and molecular mechanisms of fear memory erasure, and the roles of engram cells and perineuronal nets in memory erasure.ConclusionResearch on the mechanism of memory erasure is limited, and a plausible explanation for the essential difference between memory erasure and memory extinction still needs to be provided. Notably, this review may guide future studies on fear memory and its underlying molecular mechanisms, which may help to develop novel treatment strategies for post-traumatic stress disorder, anxiety, and other mental disorders. |
| format | Article |
| id | doaj-art-28e0cb2f81034ce68a48f3ea16dde70c |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-28e0cb2f81034ce68a48f3ea16dde70c2025-01-06T05:13:18ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-01-011510.3389/fneur.2024.14814501481450Advances in fear memory erasure and its neural mechanismsWenbo Guo0Xibo Wang1Xibo Wang2Zihan Zhou3Zihan Zhou4Yuhui Li5Yuhui Li6Yani Hou7Keyan Wang8Ruyuan Wei9Xiaoyu Ma10Hao Zhang11Institution of Traditional Chinese Medicine Innovation Research, Shandong University of Traditional Chinese Medicine, Jinan, ChinaInstitution of Traditional Chinese Medicine Innovation Research, Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of Second Clinical Medical School, Cheeloo College of Medicine, Shandong University, Jinan, ChinaInstitution of Traditional Chinese Medicine Innovation Research, Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of Public Health School, Cheeloo College of Medicine, Shandong University, Jinan, ChinaInstitution of Traditional Chinese Medicine Innovation Research, Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of Public Health School, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Rehabilitation, Medical School, Shandong Yingcai University, Jinan, ChinaSchool of Health Sciences, Shandong University of Traditional Chinese Medicine, Jinan, ChinaSchool of Anesthesia, Xuzhou Medical University, Xuzhou, ChinaDepartment of Neurology, The Second Hospital of Shandong University, Jinan, ChinaInstitution of Traditional Chinese Medicine Innovation Research, Shandong University of Traditional Chinese Medicine, Jinan, ChinaBackgroundIn nature, animals must learn to recognize danger signals and respond immediately to threats to improve their environmental adaptation. However, excessive fear responses can lead to diseases such as post-traumatic stress disorder, wherein traumatic events result in persistent traumatic memories. Therefore, erasing pathological fear memories in vivo is a crucial topic in neuroscience for understanding the nature of memories and treating clinically relevant diseases.Main textThis article reviews recent studies on fear memory erasure, erasure of short- and long-term memory, fear memory erasure and neuroplasticity, the neural circuitry and molecular mechanisms of fear memory erasure, and the roles of engram cells and perineuronal nets in memory erasure.ConclusionResearch on the mechanism of memory erasure is limited, and a plausible explanation for the essential difference between memory erasure and memory extinction still needs to be provided. Notably, this review may guide future studies on fear memory and its underlying molecular mechanisms, which may help to develop novel treatment strategies for post-traumatic stress disorder, anxiety, and other mental disorders.https://www.frontiersin.org/articles/10.3389/fneur.2024.1481450/fullfear memorymemory erasureneuroplasticityengram cellperineuronal net |
| spellingShingle | Wenbo Guo Xibo Wang Xibo Wang Zihan Zhou Zihan Zhou Yuhui Li Yuhui Li Yani Hou Keyan Wang Ruyuan Wei Xiaoyu Ma Hao Zhang Advances in fear memory erasure and its neural mechanisms Frontiers in Neurology fear memory memory erasure neuroplasticity engram cell perineuronal net |
| title | Advances in fear memory erasure and its neural mechanisms |
| title_full | Advances in fear memory erasure and its neural mechanisms |
| title_fullStr | Advances in fear memory erasure and its neural mechanisms |
| title_full_unstemmed | Advances in fear memory erasure and its neural mechanisms |
| title_short | Advances in fear memory erasure and its neural mechanisms |
| title_sort | advances in fear memory erasure and its neural mechanisms |
| topic | fear memory memory erasure neuroplasticity engram cell perineuronal net |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1481450/full |
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