Diagnostic accuracy of 4D-MRA for the detection and localization of spinal dural arteriovenous fistulas: A retrospective 10-year cohort study
Research question: The goal of this study was to assess the diagnostic accuracy of spinal time-resolved contrast-enhanced MR angiography (4D-MRA) for the detection and localization of spinal dural arteriovenous fistulas (SDAVF) in our institution. Material and methods: Single center retrospective co...
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Elsevier
2025-01-01
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| Series: | Brain and Spine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772529424014322 |
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| author | Frederick J.A. Meijer Vincent Raymaekers Sjoert A.H. Pegge Jeroen HD. Boogaarts |
| author_facet | Frederick J.A. Meijer Vincent Raymaekers Sjoert A.H. Pegge Jeroen HD. Boogaarts |
| author_sort | Frederick J.A. Meijer |
| collection | DOAJ |
| description | Research question: The goal of this study was to assess the diagnostic accuracy of spinal time-resolved contrast-enhanced MR angiography (4D-MRA) for the detection and localization of spinal dural arteriovenous fistulas (SDAVF) in our institution. Material and methods: Single center retrospective cohort study of patients with the clinical suspicion of a SDAVF. Patients were included who had undergone spinal 4D-MRA in the period January 2010–February 2021. A subgroup was identified, who had subsequent digital subtraction angiography (DSA), or clinical/radiological follow-up. Diagnostic performance measures of 4D-MRA were calculated (sensitivity, positive predictive value, specificity, and negative predictive value) with DSA serving as the reference standard. Results: Overall, 120 patients with the clinical suspicion of having a SDAVF and who underwent spinal 4D-MRA were identified. A subgroup of 30 patients had both 4D-MRA and DSA, or follow-up. In this group, the sensitivity of 4D-MRA for the detection of a SDAVF was 100% and specificity was 91% (positive predictive value of 95% and a negative predictive value of 100%). Sidedness was correctly identified on 4D-MRA in 74% of the cases and the level of the SDAVF in 68%. Discussion and conclusion: The results indicate that 4D-MRA has a high sensitivity and specificity for the detection and localization of a SDAVF, which is in line with previous studies published in literature. Furthermore, 4D-MRA can serve to guide DSA and shorten the procedural time, which reduces the risk of angiography related complications, and decreases patient discomfort. |
| format | Article |
| id | doaj-art-28c19bf992f34561b773bc8aea6bff2e |
| institution | Kabale University |
| issn | 2772-5294 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain and Spine |
| spelling | doaj-art-28c19bf992f34561b773bc8aea6bff2e2025-01-04T04:57:25ZengElsevierBrain and Spine2772-52942025-01-015104176Diagnostic accuracy of 4D-MRA for the detection and localization of spinal dural arteriovenous fistulas: A retrospective 10-year cohort studyFrederick J.A. Meijer0Vincent Raymaekers1Sjoert A.H. Pegge2Jeroen HD. Boogaarts3Department of Medical Imaging, Radboud University Medical Center, Nijmegen, the Netherlands; Corresponding author. Department of Medical Imaging, Radboudumc Geert Grooteplein 10, Postbus 9101, 6500 HB, Nijmegen, the Netherlands.Department of Neurosurgery, Antwerp University Hospital, Edegem, BelgiumDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, the NetherlandsDepartment of Neurosurgery, Radboud University Medical Center, Nijmegen, the NetherlandsResearch question: The goal of this study was to assess the diagnostic accuracy of spinal time-resolved contrast-enhanced MR angiography (4D-MRA) for the detection and localization of spinal dural arteriovenous fistulas (SDAVF) in our institution. Material and methods: Single center retrospective cohort study of patients with the clinical suspicion of a SDAVF. Patients were included who had undergone spinal 4D-MRA in the period January 2010–February 2021. A subgroup was identified, who had subsequent digital subtraction angiography (DSA), or clinical/radiological follow-up. Diagnostic performance measures of 4D-MRA were calculated (sensitivity, positive predictive value, specificity, and negative predictive value) with DSA serving as the reference standard. Results: Overall, 120 patients with the clinical suspicion of having a SDAVF and who underwent spinal 4D-MRA were identified. A subgroup of 30 patients had both 4D-MRA and DSA, or follow-up. In this group, the sensitivity of 4D-MRA for the detection of a SDAVF was 100% and specificity was 91% (positive predictive value of 95% and a negative predictive value of 100%). Sidedness was correctly identified on 4D-MRA in 74% of the cases and the level of the SDAVF in 68%. Discussion and conclusion: The results indicate that 4D-MRA has a high sensitivity and specificity for the detection and localization of a SDAVF, which is in line with previous studies published in literature. Furthermore, 4D-MRA can serve to guide DSA and shorten the procedural time, which reduces the risk of angiography related complications, and decreases patient discomfort.http://www.sciencedirect.com/science/article/pii/S2772529424014322SpineNeurovascularMagnetic resonance imagingAngiography |
| spellingShingle | Frederick J.A. Meijer Vincent Raymaekers Sjoert A.H. Pegge Jeroen HD. Boogaarts Diagnostic accuracy of 4D-MRA for the detection and localization of spinal dural arteriovenous fistulas: A retrospective 10-year cohort study Brain and Spine Spine Neurovascular Magnetic resonance imaging Angiography |
| title | Diagnostic accuracy of 4D-MRA for the detection and localization of spinal dural arteriovenous fistulas: A retrospective 10-year cohort study |
| title_full | Diagnostic accuracy of 4D-MRA for the detection and localization of spinal dural arteriovenous fistulas: A retrospective 10-year cohort study |
| title_fullStr | Diagnostic accuracy of 4D-MRA for the detection and localization of spinal dural arteriovenous fistulas: A retrospective 10-year cohort study |
| title_full_unstemmed | Diagnostic accuracy of 4D-MRA for the detection and localization of spinal dural arteriovenous fistulas: A retrospective 10-year cohort study |
| title_short | Diagnostic accuracy of 4D-MRA for the detection and localization of spinal dural arteriovenous fistulas: A retrospective 10-year cohort study |
| title_sort | diagnostic accuracy of 4d mra for the detection and localization of spinal dural arteriovenous fistulas a retrospective 10 year cohort study |
| topic | Spine Neurovascular Magnetic resonance imaging Angiography |
| url | http://www.sciencedirect.com/science/article/pii/S2772529424014322 |
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