A case report on overlap syndrome: diagnostic and management challenges
Overlap syndromes are inflammatory rheumatic conditions in which patients show clinical manifestations suggestive of multiple distinct immune diseases. This case report discusses a complex instance involving Sjögren’s disease, rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE) in a wo...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2024-06-01
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| Series: | Romanian Journal of Rheumatology |
| Subjects: | |
| Online Access: | https://rjr.com.ro/articles/2024.2/RJR_2024_2_Art-08.pdf |
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| _version_ | 1846120341219311616 |
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| author | Jibin Simon Saranya C. Indhumati E. Ananthakumar P.K. Manoj Sivasamy Sharan Bose |
| author_facet | Jibin Simon Saranya C. Indhumati E. Ananthakumar P.K. Manoj Sivasamy Sharan Bose |
| author_sort | Jibin Simon |
| collection | DOAJ |
| description | Overlap syndromes are inflammatory rheumatic conditions in which patients show clinical manifestations suggestive of multiple distinct immune diseases. This case report discusses a complex instance involving Sjögren’s disease, rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE) in a woman in her 30s. Lupus nephritis, a severe kidney inflammation associated with SLE, and diffuse alveolar hemorrhage (DAH), a life-threatening lung complication characterized by bleeding into the alveolar spaces, further complicated her clinical course. Initially presenting with acute lower limb pain, swelling, and rash, suggesting systemic involvement beyond RA, laboratory findings of hypocomplementemia and renal involvement raised suspicion of SLE. The subsequent development of polyserositis, mesenteric vasculitis, and DAH underscored the complexity of her condition. This case highlights the importance of a holistic approach that integrates clinical expertise, advanced diagnostics, and tailored therapeutic interventions to optimize patient outcomes. Early recognition and prompt management of complications are crucial in mitigating morbidity and improving prognosis, emphasizing the need for vigilant monitoring and interdisciplinary collaboration in the management of connective tissue diseases. |
| format | Article |
| id | doaj-art-28b99d6eef644a4bb43fede6a2f4a09a |
| institution | Kabale University |
| issn | 1843-0791 2069-6086 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Rheumatology |
| spelling | doaj-art-28b99d6eef644a4bb43fede6a2f4a09a2024-12-16T11:52:23ZengAmaltea Medical Publishing HouseRomanian Journal of Rheumatology1843-07912069-60862024-06-0133211912410.37897/RJR.2024.2.8A case report on overlap syndrome: diagnostic and management challengesJibin Simon0Saranya C.1Indhumati E.2Ananthakumar P.K.3Manoj Sivasamy4Sharan Bose5Department of General Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, IndiaDepartment of Rheumatology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, IndiaDepartment of Nephrology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, IndiaDepartment of General Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, IndiaDepartment of General Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, IndiaDepartment of General Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India Overlap syndromes are inflammatory rheumatic conditions in which patients show clinical manifestations suggestive of multiple distinct immune diseases. This case report discusses a complex instance involving Sjögren’s disease, rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE) in a woman in her 30s. Lupus nephritis, a severe kidney inflammation associated with SLE, and diffuse alveolar hemorrhage (DAH), a life-threatening lung complication characterized by bleeding into the alveolar spaces, further complicated her clinical course. Initially presenting with acute lower limb pain, swelling, and rash, suggesting systemic involvement beyond RA, laboratory findings of hypocomplementemia and renal involvement raised suspicion of SLE. The subsequent development of polyserositis, mesenteric vasculitis, and DAH underscored the complexity of her condition. This case highlights the importance of a holistic approach that integrates clinical expertise, advanced diagnostics, and tailored therapeutic interventions to optimize patient outcomes. Early recognition and prompt management of complications are crucial in mitigating morbidity and improving prognosis, emphasizing the need for vigilant monitoring and interdisciplinary collaboration in the management of connective tissue diseases.https://rjr.com.ro/articles/2024.2/RJR_2024_2_Art-08.pdfconnective tissue diseasesoverlap syndromerheumatoid arthritissjögren’s syndromesystemic lupus erythematosusrenal involvementdiffuse alveolar hemorrhage |
| spellingShingle | Jibin Simon Saranya C. Indhumati E. Ananthakumar P.K. Manoj Sivasamy Sharan Bose A case report on overlap syndrome: diagnostic and management challenges Romanian Journal of Rheumatology connective tissue diseases overlap syndrome rheumatoid arthritis sjögren’s syndrome systemic lupus erythematosus renal involvement diffuse alveolar hemorrhage |
| title | A case report on overlap syndrome: diagnostic and management challenges |
| title_full | A case report on overlap syndrome: diagnostic and management challenges |
| title_fullStr | A case report on overlap syndrome: diagnostic and management challenges |
| title_full_unstemmed | A case report on overlap syndrome: diagnostic and management challenges |
| title_short | A case report on overlap syndrome: diagnostic and management challenges |
| title_sort | case report on overlap syndrome diagnostic and management challenges |
| topic | connective tissue diseases overlap syndrome rheumatoid arthritis sjögren’s syndrome systemic lupus erythematosus renal involvement diffuse alveolar hemorrhage |
| url | https://rjr.com.ro/articles/2024.2/RJR_2024_2_Art-08.pdf |
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