Myeloid-specific deletion of autotaxin inhibits rheumatoid arthritis and osteoclastogenesis

Myeloid-specific deletion of autotaxin inhibits rheumatoid arthritis and osteoclastogenesis

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint swelling, pain, and bone remodeling. We previously reported that autotaxin (ATX) deficiency disrupts lipid rafts in macrophages. Lipid raft disruption results in the dysregulation of RANK signaling, which is crucial for...

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Bibliographic Details
Main Authors: Gwangbeom Heo, Sihyun Jeong, Soyeong Park, Su Jin Kim, Yunna Lee, Seong Ji Woo, Kyunghwan Kim, Byung-Hyun Park, Sang Hoon Rhee, Eunok Im
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
autotaxin
lipid rafts
osteoclastogenesis
collagen-induced arthritis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1481699/full
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