Predicting the hub interactome of COVID-19 and oral squamous cell carcinoma: uncovering ALDH-mediated Wnt/β-catenin pathway activation via salivary inflammatory proteins

Predicting the hub interactome of COVID-19 and oral squamous cell carcinoma: uncovering ALDH-mediated Wnt/β-catenin pathway activation via salivary inflammatory proteins

Abstract Understanding shared pathways and mechanisms involved in the pathogenesis of diseases like oral squamous cell carcinoma (OSCC) and COVID-19 could lead to the development of novel therapeutic strategies and diagnostic biomarkers. This study aims to predict the interactome of OSCC and COVID-1...

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Bibliographic Details
Main Authors: Pradeep Kumar Yadalam, Deepavalli Arumuganainar, Prabhu Manickam Natarajan, Carlos M. Ardila
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Oral cancer
COVID-19
Hub proteins
Interactome
Machine learning
Online Access:https://doi.org/10.1038/s41598-025-88819-2
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