RNA methylation in neurodevelopment and related diseases
Biological development and genetic information transfer are governed by genetic, epigenetic, transcriptional, and posttranscriptional mechanisms. RNA methylation, the attachment of methyl (–CH<sub>3</sub>) groups to RNA molecules,...
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| Format: | Article |
| Language: | English |
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China Science Publishing & Media Ltd.
2024-09-01
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| Series: | Acta Biochimica et Biophysica Sinica |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2024159 |
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| _version_ | 1841525834561617920 |
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| author | Xia Wenjuan Liu Yue Lu Jiafeng Cheung Hoi-Hung Meng Qingxia Huang Boxian |
| author_facet | Xia Wenjuan Liu Yue Lu Jiafeng Cheung Hoi-Hung Meng Qingxia Huang Boxian |
| author_sort | Xia Wenjuan |
| collection | DOAJ |
| description | Biological development and genetic information transfer are governed by genetic, epigenetic, transcriptional, and posttranscriptional mechanisms. RNA methylation, the attachment of methyl (–CH<sub>3</sub>) groups to RNA molecules, is a posttranscriptional modification that has gained increasing attention in recent years because of its role in RNA epitranscriptomics. RNA modifications (RMs) influence various aspects of RNA metabolism and are involved in the regulation of diverse biological processes and diseases. Neural cell types emerge at specific stages of brain development, and recent studies have revealed that neurodevelopment, aging, and disease are tightly linked to transcriptome dysregulation. In this review, we discuss the roles of N6-methyladenine (m6A) and 5-methylcytidine (m5C) RNA modifications in neurodevelopment, physiological functions, and related diseases. |
| format | Article |
| id | doaj-art-286aac56c69b43cdad809550d2992fb5 |
| institution | Kabale University |
| issn | 1672-9145 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj-art-286aac56c69b43cdad809550d2992fb52025-01-17T05:58:30ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452024-09-01561723173210.3724/abbs.202415920d259ccRNA methylation in neurodevelopment and related diseasesXia Wenjuan0Liu Yue1Lu Jiafeng2Cheung Hoi-Hung3Meng Qingxia4Huang Boxian5["State Key Laboratory of Reproductive Medicine and Offspring Health (Suzhou), Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215002, China"]["State Key Laboratory of Reproductive Medicine and Offspring Health (Suzhou), Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215002, China"]["State Key Laboratory of Reproductive Medicine and Offspring Health (Suzhou), Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215002, China"]["School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China"]["State Key Laboratory of Reproductive Medicine and Offspring Health (Suzhou), Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215002, China"]["State Key Laboratory of Reproductive Medicine and Offspring Health (Suzhou), Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215002, China"]Biological development and genetic information transfer are governed by genetic, epigenetic, transcriptional, and posttranscriptional mechanisms. RNA methylation, the attachment of methyl (–CH<sub>3</sub>) groups to RNA molecules, is a posttranscriptional modification that has gained increasing attention in recent years because of its role in RNA epitranscriptomics. RNA modifications (RMs) influence various aspects of RNA metabolism and are involved in the regulation of diverse biological processes and diseases. Neural cell types emerge at specific stages of brain development, and recent studies have revealed that neurodevelopment, aging, and disease are tightly linked to transcriptome dysregulation. In this review, we discuss the roles of N6-methyladenine (m6A) and 5-methylcytidine (m5C) RNA modifications in neurodevelopment, physiological functions, and related diseases.https://www.sciengine.com/doi/10.3724/abbs.2024159RNA methylationneurodevelopmentN6-methyladenine (m6A)5-methylcytidine (m5C) |
| spellingShingle | Xia Wenjuan Liu Yue Lu Jiafeng Cheung Hoi-Hung Meng Qingxia Huang Boxian RNA methylation in neurodevelopment and related diseases Acta Biochimica et Biophysica Sinica RNA methylation neurodevelopment N6-methyladenine (m6A) 5-methylcytidine (m5C) |
| title | RNA methylation in neurodevelopment and related diseases |
| title_full | RNA methylation in neurodevelopment and related diseases |
| title_fullStr | RNA methylation in neurodevelopment and related diseases |
| title_full_unstemmed | RNA methylation in neurodevelopment and related diseases |
| title_short | RNA methylation in neurodevelopment and related diseases |
| title_sort | rna methylation in neurodevelopment and related diseases |
| topic | RNA methylation neurodevelopment N6-methyladenine (m6A) 5-methylcytidine (m5C) |
| url | https://www.sciengine.com/doi/10.3724/abbs.2024159 |
| work_keys_str_mv | AT xiawenjuan rnamethylationinneurodevelopmentandrelateddiseases AT liuyue rnamethylationinneurodevelopmentandrelateddiseases AT lujiafeng rnamethylationinneurodevelopmentandrelateddiseases AT cheunghoihung rnamethylationinneurodevelopmentandrelateddiseases AT mengqingxia rnamethylationinneurodevelopmentandrelateddiseases AT huangboxian rnamethylationinneurodevelopmentandrelateddiseases |