The prodrome of migraine: mechanistic insights and emerging therapeutic strategies
Migraine is a common clinical chronic neurovascular disease characterized by recurrent, mostly unilateral, moderate or severe, pulsatile headache. It can be divided into four clinical stages: premonitory (prodrome), aura, headache and postdrome. The early warning value of the prodrome in migraine ha...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-11-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1496401/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846150227743997952 |
|---|---|
| author | Linli Gao Linli Gao Fangling Zhao Yujie Tu Kaiming Liu |
| author_facet | Linli Gao Linli Gao Fangling Zhao Yujie Tu Kaiming Liu |
| author_sort | Linli Gao |
| collection | DOAJ |
| description | Migraine is a common clinical chronic neurovascular disease characterized by recurrent, mostly unilateral, moderate or severe, pulsatile headache. It can be divided into four clinical stages: premonitory (prodrome), aura, headache and postdrome. The early warning value of the prodrome in migraine has been largely verified in various studies. In fact, the prodrome of migraine has received increasing attention as it can serve as an ideal therapeutic window for early intervention and effective treatment of migraine. In recent years, the pathophysiological and molecular biological mechanisms in the prodromal stage of migraine have been extensively studied, and great progress has been made in understanding the disease. This review paper aims to provide an overview of recent studies mainly focused on the prodrome of migraine, discuss the biological mechanisms underlying the clinical profile, and reveal novel therapeutic strategies for preventing or blocking migraine onset during its prodrome. |
| format | Article |
| id | doaj-art-285f15a51ecc47e9be18eb4028d47cc3 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-285f15a51ecc47e9be18eb4028d47cc32024-11-29T05:10:13ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-11-011510.3389/fneur.2024.14964011496401The prodrome of migraine: mechanistic insights and emerging therapeutic strategiesLinli Gao0Linli Gao1Fangling Zhao2Yujie Tu3Kaiming Liu4Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaCardiovascular Key Laboratory of Zhejiang Province, Hangzhou, ChinaDepartment of Neurology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurology, Affiliated Hospital of Shaoxing University, Shaoxing, ChinaDepartment of Neurology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaMigraine is a common clinical chronic neurovascular disease characterized by recurrent, mostly unilateral, moderate or severe, pulsatile headache. It can be divided into four clinical stages: premonitory (prodrome), aura, headache and postdrome. The early warning value of the prodrome in migraine has been largely verified in various studies. In fact, the prodrome of migraine has received increasing attention as it can serve as an ideal therapeutic window for early intervention and effective treatment of migraine. In recent years, the pathophysiological and molecular biological mechanisms in the prodromal stage of migraine have been extensively studied, and great progress has been made in understanding the disease. This review paper aims to provide an overview of recent studies mainly focused on the prodrome of migraine, discuss the biological mechanisms underlying the clinical profile, and reveal novel therapeutic strategies for preventing or blocking migraine onset during its prodrome.https://www.frontiersin.org/articles/10.3389/fneur.2024.1496401/fullmigraineprodrometreatment strategyheadachebiological mechanisms |
| spellingShingle | Linli Gao Linli Gao Fangling Zhao Yujie Tu Kaiming Liu The prodrome of migraine: mechanistic insights and emerging therapeutic strategies Frontiers in Neurology migraine prodrome treatment strategy headache biological mechanisms |
| title | The prodrome of migraine: mechanistic insights and emerging therapeutic strategies |
| title_full | The prodrome of migraine: mechanistic insights and emerging therapeutic strategies |
| title_fullStr | The prodrome of migraine: mechanistic insights and emerging therapeutic strategies |
| title_full_unstemmed | The prodrome of migraine: mechanistic insights and emerging therapeutic strategies |
| title_short | The prodrome of migraine: mechanistic insights and emerging therapeutic strategies |
| title_sort | prodrome of migraine mechanistic insights and emerging therapeutic strategies |
| topic | migraine prodrome treatment strategy headache biological mechanisms |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1496401/full |
| work_keys_str_mv | AT linligao theprodromeofmigrainemechanisticinsightsandemergingtherapeuticstrategies AT linligao theprodromeofmigrainemechanisticinsightsandemergingtherapeuticstrategies AT fanglingzhao theprodromeofmigrainemechanisticinsightsandemergingtherapeuticstrategies AT yujietu theprodromeofmigrainemechanisticinsightsandemergingtherapeuticstrategies AT kaimingliu theprodromeofmigrainemechanisticinsightsandemergingtherapeuticstrategies AT linligao prodromeofmigrainemechanisticinsightsandemergingtherapeuticstrategies AT linligao prodromeofmigrainemechanisticinsightsandemergingtherapeuticstrategies AT fanglingzhao prodromeofmigrainemechanisticinsightsandemergingtherapeuticstrategies AT yujietu prodromeofmigrainemechanisticinsightsandemergingtherapeuticstrategies AT kaimingliu prodromeofmigrainemechanisticinsightsandemergingtherapeuticstrategies |