Laser Desorption/Ionization on Au@TiO<sub>2</sub> Core@Shell Nanostars for Mass Spectrometric Analysis of Small Molecules
The core@shell nanostars composed of star-like Au nanocores with TiO<sub>2</sub> shells (Au@TiO<sub>2</sub> NSs) are synthesized in a one-pot reaction without any reducing or surface-controlling agents. The Au@TiO<sub>2</sub> NSs exhibit strong absorption in the U...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
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| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/14/23/1946 |
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| Summary: | The core@shell nanostars composed of star-like Au nanocores with TiO<sub>2</sub> shells (Au@TiO<sub>2</sub> NSs) are synthesized in a one-pot reaction without any reducing or surface-controlling agents. The Au@TiO<sub>2</sub> NSs exhibit strong absorption in the UV region based on the interaction between the Au nanocore and the TiO<sub>2</sub> shell, and this optochemical property leads to the efficient laser desorption/ionization time-of-flight mass spectrometry (LDI-TOF-MS) analysis of small molecules with low background interference and high reproducible mass signals compared with spherical Au nanoparticles (NPs). The limit of detection and dynamic range values of various analytes also improved with Au@TiO<sub>2</sub> NSs compared with those obtained with spherical Au NPs. Our findings successfully demonstrate that Au@TiO<sub>2</sub> NSs are a promising matrix for the LDI-TOF-MS analysis of various small molecules as well as synthetic polymers. |
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| ISSN: | 2079-4991 |