The impact of inflammatory bowel diseases on the development of atherosclerosis and cardiovascular risk
Objective: To study the impact of inflammatory bowel diseases (IBD) on the development of atherosclerosis and assess cardiovascular risk in patients without established cardiovascular pathology. Materials and Methods. The study included 115 patients divided into three groups: 37 patients with Crohn’...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
InterMedservice
2025-06-01
|
| Series: | Евразийский Кардиологический Журнал |
| Subjects: | |
| Online Access: | https://www.heartj.asia/jour/article/view/6519 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849244969939763200 |
|---|---|
| author | G. O. Isaev O. Iu. Trushina M. A. Isaikina A. A. Bestavashvili E. S. Zadykyan M. V. Yurazh Ph. Yu. Kopylov M. H. Mnatsakanyan V. V. Fomin |
| author_facet | G. O. Isaev O. Iu. Trushina M. A. Isaikina A. A. Bestavashvili E. S. Zadykyan M. V. Yurazh Ph. Yu. Kopylov M. H. Mnatsakanyan V. V. Fomin |
| author_sort | G. O. Isaev |
| collection | DOAJ |
| description | Objective: To study the impact of inflammatory bowel diseases (IBD) on the development of atherosclerosis and assess cardiovascular risk in patients without established cardiovascular pathology. Materials and Methods. The study included 115 patients divided into three groups: 37 patients with Crohn’s disease (CD), 44 patients with ulcerative colitis (UC), and 34 patients in a control group without signs of IBD or other risk factors. All participants underwent carotid artery ultrasound (CAU), assessment of 10-year cardiovascular risk using the Framingham scale, and evaluation of basic laboratory parameters. Results. Patients with IBD demonstrated an increased intima-media thickness (IMT) of the common carotid artery (CCA): in the UC group, the IMT on the right side was 0.08 cm, and on the left side was 0.07 cm (p=0.019 and p=0.012, respectively); in the CD group, the IMT was 0.07 cm (p=0.001). In the control group, the IMT was 0.06 cm. Levels of C-reactive protein (CRP) and fibrinogen were significantly higher in the IBD groups compared to controls. The calculation of 10-year cardiovascular risk using the Framingham scale revealed no significant differences between the groups: the median risk was 1.54% [0.99-2.68] for the CD group, 1.59% [1.25-2.7] for the UC group, and 1.32% [1.04-2.17] for the control group (p=0.625). The number of patients with moderate and high risk (>10%) also did not differ significantly between the groups (p=0.135). Conclusion: IBD is associated with thickening of vascular walls and elevated levels of inflammatory markers, which may indicate an increased risk of developing atherosclerosis. However, the cardiovascular risk calculated using the Framingham scale did not differ significantly between the groups, highlighting the potential need for additional risk assessment in patients with IBD. |
| format | Article |
| id | doaj-art-281e3dd8795d4c82a188bcd3a9ce9e73 |
| institution | Kabale University |
| issn | 2225-1685 2305-0748 |
| language | Russian |
| publishDate | 2025-06-01 |
| publisher | InterMedservice |
| record_format | Article |
| series | Евразийский Кардиологический Журнал |
| spelling | doaj-art-281e3dd8795d4c82a188bcd3a9ce9e732025-08-20T03:58:59ZrusInterMedserviceЕвразийский Кардиологический Журнал2225-16852305-07482025-06-0102586410.38109/2225-1685-2025-2-58-646381The impact of inflammatory bowel diseases on the development of atherosclerosis and cardiovascular riskG. O. Isaev0O. Iu. Trushina1M. A. Isaikina2A. A. Bestavashvili3E. S. Zadykyan4M. V. Yurazh5Ph. Yu. Kopylov6M. H. Mnatsakanyan7V. V. Fomin8I.M. Sechenov first Moscow state medical university (Sechenov University)I.M. Sechenov first Moscow state medical university (Sechenov University)I.M. Sechenov first Moscow state medical university (Sechenov University)I.M. Sechenov first Moscow state medical university (Sechenov University)I.M. Sechenov first Moscow state medical university (Sechenov University)I.M. Sechenov first Moscow state medical university (Sechenov University)I.M. Sechenov first Moscow state medical university (Sechenov University)I.M. Sechenov first Moscow state medical university (Sechenov University)I.M. Sechenov first Moscow state medical university (Sechenov University)Objective: To study the impact of inflammatory bowel diseases (IBD) on the development of atherosclerosis and assess cardiovascular risk in patients without established cardiovascular pathology. Materials and Methods. The study included 115 patients divided into three groups: 37 patients with Crohn’s disease (CD), 44 patients with ulcerative colitis (UC), and 34 patients in a control group without signs of IBD or other risk factors. All participants underwent carotid artery ultrasound (CAU), assessment of 10-year cardiovascular risk using the Framingham scale, and evaluation of basic laboratory parameters. Results. Patients with IBD demonstrated an increased intima-media thickness (IMT) of the common carotid artery (CCA): in the UC group, the IMT on the right side was 0.08 cm, and on the left side was 0.07 cm (p=0.019 and p=0.012, respectively); in the CD group, the IMT was 0.07 cm (p=0.001). In the control group, the IMT was 0.06 cm. Levels of C-reactive protein (CRP) and fibrinogen were significantly higher in the IBD groups compared to controls. The calculation of 10-year cardiovascular risk using the Framingham scale revealed no significant differences between the groups: the median risk was 1.54% [0.99-2.68] for the CD group, 1.59% [1.25-2.7] for the UC group, and 1.32% [1.04-2.17] for the control group (p=0.625). The number of patients with moderate and high risk (>10%) also did not differ significantly between the groups (p=0.135). Conclusion: IBD is associated with thickening of vascular walls and elevated levels of inflammatory markers, which may indicate an increased risk of developing atherosclerosis. However, the cardiovascular risk calculated using the Framingham scale did not differ significantly between the groups, highlighting the potential need for additional risk assessment in patients with IBD.https://www.heartj.asia/jour/article/view/6519inflammatory bowel diseasesatherosclerosiscardiovascular riskframingham scalecarotid artery ultrasoundc-reactive proteinfibrinogenintima-media thicknessinflammationprognosis |
| spellingShingle | G. O. Isaev O. Iu. Trushina M. A. Isaikina A. A. Bestavashvili E. S. Zadykyan M. V. Yurazh Ph. Yu. Kopylov M. H. Mnatsakanyan V. V. Fomin The impact of inflammatory bowel diseases on the development of atherosclerosis and cardiovascular risk Евразийский Кардиологический Журнал inflammatory bowel diseases atherosclerosis cardiovascular risk framingham scale carotid artery ultrasound c-reactive protein fibrinogen intima-media thickness inflammation prognosis |
| title | The impact of inflammatory bowel diseases on the development of atherosclerosis and cardiovascular risk |
| title_full | The impact of inflammatory bowel diseases on the development of atherosclerosis and cardiovascular risk |
| title_fullStr | The impact of inflammatory bowel diseases on the development of atherosclerosis and cardiovascular risk |
| title_full_unstemmed | The impact of inflammatory bowel diseases on the development of atherosclerosis and cardiovascular risk |
| title_short | The impact of inflammatory bowel diseases on the development of atherosclerosis and cardiovascular risk |
| title_sort | impact of inflammatory bowel diseases on the development of atherosclerosis and cardiovascular risk |
| topic | inflammatory bowel diseases atherosclerosis cardiovascular risk framingham scale carotid artery ultrasound c-reactive protein fibrinogen intima-media thickness inflammation prognosis |
| url | https://www.heartj.asia/jour/article/view/6519 |
| work_keys_str_mv | AT goisaev theimpactofinflammatoryboweldiseasesonthedevelopmentofatherosclerosisandcardiovascularrisk AT oiutrushina theimpactofinflammatoryboweldiseasesonthedevelopmentofatherosclerosisandcardiovascularrisk AT maisaikina theimpactofinflammatoryboweldiseasesonthedevelopmentofatherosclerosisandcardiovascularrisk AT aabestavashvili theimpactofinflammatoryboweldiseasesonthedevelopmentofatherosclerosisandcardiovascularrisk AT eszadykyan theimpactofinflammatoryboweldiseasesonthedevelopmentofatherosclerosisandcardiovascularrisk AT mvyurazh theimpactofinflammatoryboweldiseasesonthedevelopmentofatherosclerosisandcardiovascularrisk AT phyukopylov theimpactofinflammatoryboweldiseasesonthedevelopmentofatherosclerosisandcardiovascularrisk AT mhmnatsakanyan theimpactofinflammatoryboweldiseasesonthedevelopmentofatherosclerosisandcardiovascularrisk AT vvfomin theimpactofinflammatoryboweldiseasesonthedevelopmentofatherosclerosisandcardiovascularrisk AT goisaev impactofinflammatoryboweldiseasesonthedevelopmentofatherosclerosisandcardiovascularrisk AT oiutrushina impactofinflammatoryboweldiseasesonthedevelopmentofatherosclerosisandcardiovascularrisk AT maisaikina impactofinflammatoryboweldiseasesonthedevelopmentofatherosclerosisandcardiovascularrisk AT aabestavashvili impactofinflammatoryboweldiseasesonthedevelopmentofatherosclerosisandcardiovascularrisk AT eszadykyan impactofinflammatoryboweldiseasesonthedevelopmentofatherosclerosisandcardiovascularrisk AT mvyurazh impactofinflammatoryboweldiseasesonthedevelopmentofatherosclerosisandcardiovascularrisk AT phyukopylov impactofinflammatoryboweldiseasesonthedevelopmentofatherosclerosisandcardiovascularrisk AT mhmnatsakanyan impactofinflammatoryboweldiseasesonthedevelopmentofatherosclerosisandcardiovascularrisk AT vvfomin impactofinflammatoryboweldiseasesonthedevelopmentofatherosclerosisandcardiovascularrisk |