Targeting chromosomally unstable tumors with a selective KIF18A inhibitor

Targeting chromosomally unstable tumors with a selective KIF18A inhibitor

Abstract Chromosome instability is a prevalent vulnerability of cancer cells that has yet to be fully exploited therapeutically. To identify genes uniquely essential to chromosomally unstable cells, we mined the Cancer Dependency Map for genes essential in tumor cells with high levels of copy number...

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Main Authors: Aaron F. Phillips, Rumin Zhang, Mia Jaffe, Ryan Schulz, Marysol Chu Carty, Akanksha Verma, Tamar Y. Feinberg, Michael D. Arensman, Alan Chiu, Reka Letso, Nazario Bosco, Katelyn A. Queen, Allison R. Racela, Jason Stumpff, Celia Andreu-Agullo, Sarah E. Bettigole, Rafael S. Depetris, Scott Drutman, Shinsan M. Su, Derek A. Cogan, Christina H. Eng
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55300-z
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