Systematic analysis of bypass suppression of essential genes

Systematic analysis of bypass suppression of essential genes

Abstract Essential genes tend to be highly conserved across eukaryotes, but, in some cases, their critical roles can be bypassed through genetic rewiring. From a systematic analysis of 728 different essential yeast genes, we discovered that 124 (17%) were dispensable essential genes. Through whole‐g...

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Main Authors: Jolanda van Leeuwen, Carles Pons, Guihong Tan, Zi Yang Wang, Jing Hou, Jochen Weile, Marinella Gebbia, Wendy Liang, Ermira Shuteriqi, Zhijian Li, Maykel Lopes, Matej Ušaj, Andreia Dos Santos Lopes, Natascha van Lieshout, Chad L Myers, Frederick P Roth, Patrick Aloy, Brenda J Andrews, Charles Boone
Format: Article
Language:English
Published: Springer Nature 2020-09-01
Series:Molecular Systems Biology
Subjects:
compensatory evolution
gene essentiality
genetic interactions
genetic networks
genetic suppression
Online Access:https://doi.org/10.15252/msb.20209828
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